{"id":"W2599078623","doi":"10.1128/iai.00942-16","title":"Bile Acid Administration Elicits an Intestinal Antimicrobial Program and Reduces the Bacterial Burden in Two Mouse Models of Enteric Infection","year":2017,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; Université de Sherbrooke","funders":"Crohn's and Colitis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Chenodeoxycholic acid; Biology; Bile acid; Farnesoid X receptor; Microbiology; Ileum; Antimicrobial; Paneth cell; Salmonella enterica; Immune system; Deoxycholic acid; Immunology; Salmonella; Biochemistry; Bacteria; Small intestine; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005427558,0.001557276,0.0009675265,0.002064694,0.0003714656,0.0006902813,0.0004356148,0.001259301,0.001400766],"category_scores_gemma":[0.0002567424,0.000610017,0.0008359486,0.0004779406,0.0007117073,0.0005646241,0.0004402265,0.002270153,0.0004793578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005020431,"about_ca_system_score_gemma":0.0003775209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005029528,"about_ca_topic_score_gemma":0.001042254,"domain_scores_codex":[0.9992238,0.0001602656,0.0001142024,0.0001623785,0.0001517669,0.0001874983],"domain_scores_gemma":[0.9992072,0.00004595421,0.000249044,0.00008080104,0.00006504556,0.000351995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001145177,0.0005107183,0.0003359254,0.00008059508,0.00001637958,0.00009818017,0.0000377752,0.00005583771,0.9966156,0.00005721732,0.00005573258,0.0009908038],"study_design_scores_gemma":[0.0002607415,0.009180548,0.0102553,0.00005605927,0.0001152784,0.000664461,0.00017646,0.001119187,0.9756078,0.0001386093,0.002393244,0.00003231819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900436,0.002432259,0.004205101,0.0003732441,0.0001374871,0.0001750394,0.001138683,0.0002888879,0.001205653],"genre_scores_gemma":[0.9810486,0.002558314,0.006604651,0.0003077715,0.00005689211,0.000550459,0.001610702,0.0001152232,0.00714739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002064694,"threshold_uncertainty_score":0.004686058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424930019683387,"score_gpt":0.3316927508518778,"score_spread":0.307443450655044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}