{"id":"W2599078623","doi":"10.1128/iai.00942-16","title":"Bile Acid Administration Elicits an Intestinal Antimicrobial Program and Reduces the Bacterial Burden in Two Mouse Models of Enteric Infection","year":2017,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia; Université de Sherbrooke","funders":"Crohn's and Colitis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Chenodeoxycholic acid; Biology; Bile acid; Farnesoid X receptor; Microbiology; Ileum; Antimicrobial; Paneth cell; Salmonella enterica; Immune system; Deoxycholic acid; Immunology; Salmonella; Biochemistry; Bacteria; Small intestine; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002687412,0.00008447636,0.00009605294,0.00003770144,0.0002763936,0.00008309563,0.00005368863,0.00007958387,0.00000228183],"category_scores_gemma":[0.00005771723,0.00005908781,0.00002165329,0.00003074521,0.0001504326,0.00003507319,0.00006034806,0.0001117715,3.479968e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008383501,"about_ca_system_score_gemma":0.00004883469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003650795,"about_ca_topic_score_gemma":0.0008180285,"domain_scores_codex":[0.999415,0.0001551694,0.0001705731,0.0001306804,0.00003576982,0.00009284126],"domain_scores_gemma":[0.9995452,0.00000482134,0.000161876,0.0001838468,0.00007010227,0.00003414896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715022,0.0001603897,0.01933585,0.00003584276,0.00001428389,2.871472e-7,0.000199136,0.0000315822,0.9620304,0.00002300623,0.000009756819,0.01798798],"study_design_scores_gemma":[0.001586486,0.002351603,0.29226,0.0001295103,0.00002437284,0.0001330059,0.00008927481,0.0009105831,0.7011824,0.00006541182,0.001066445,0.0002008728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989645,0.00002980452,0.00007734267,0.00005700501,0.0001902649,0.0002859062,0.000006364295,0.00001105067,0.0003777724],"genre_scores_gemma":[0.9992923,0.0004328968,0.00003951582,0.000009061953,0.0001086532,0.00001748982,0.00005851138,0.000006046835,0.00003550149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2729242,"threshold_uncertainty_score":0.5518935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424930019683387,"score_gpt":0.3316927508518778,"score_spread":0.307443450655044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}