{"id":"W2599098340","doi":"10.1016/j.cllc.2017.03.010","title":"LUME-Meso: Design and Rationale of the Phase III Part of a Placebo-Controlled Study of Nintedanib and Pemetrexed/Cisplatin Followed by Maintenance Nintedanib in Patients With Unresectable Malignant Pleural Mesothelioma","year":2017,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Nintedanib; Pemetrexed; Medicine; Bevacizumab; Oncology; Internal medicine; Mesothelioma; Clinical endpoint; Maintenance therapy; Vascular endothelial growth factor; Carboplatin; Interim analysis; Cisplatin; Surgery; Chemotherapy; Clinical trial; Pathology; Idiopathic pulmonary fibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004842643,0.0001525095,0.0006742615,0.00004287804,0.00008109521,0.00001013859,0.0001445486,0.00005480908,0.00009728174],"category_scores_gemma":[0.0004882774,0.00008880292,0.00008525122,0.00007628756,0.0003970917,0.00009255688,0.00009771046,0.0001164364,1.972658e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004052529,"about_ca_system_score_gemma":0.00009938017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203374,"about_ca_topic_score_gemma":0.000116866,"domain_scores_codex":[0.998266,0.0001617099,0.0007251519,0.0002892675,0.000405133,0.0001527418],"domain_scores_gemma":[0.9984247,0.0004215461,0.0006259051,0.0003285498,0.0001040197,0.00009527672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04997315,0.002387061,0.9441754,0.00007830605,0.0002906536,0.000002769443,0.0001295512,0.00004632181,0.0007168918,0.00001183875,0.001612533,0.0005755031],"study_design_scores_gemma":[0.1017361,0.002565092,0.8910145,0.0005846333,0.0004522405,7.153044e-7,0.000169199,0.002761964,0.0005628382,0.00002037536,0.00002959341,0.0001028135],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967922,0.000435837,0.00003859658,0.0001596603,0.00007802489,0.002262963,0.0001383311,0.000003733667,0.00009067886],"genre_scores_gemma":[0.9989414,0.00007273477,0.0001164874,0.00006583935,0.00002088087,0.0001270444,0.00001298558,0.00001469966,0.0006279673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05316094,"threshold_uncertainty_score":0.3621278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02408420042486542,"score_gpt":0.3455455358566427,"score_spread":0.3214613354317772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}