{"id":"W2599151356","doi":"10.1101/116822","title":"Genotoxin-induced transcriptional repression regulates selective protein aggregation","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Chromatin; RNA splicing; Cell biology; Splicing factor; Biology; Proteome; Transcriptome; Transcription factor; Psychological repression; Chromatin remodeling; Cytoplasm; Ribosomal protein; Gene; Transcriptional regulation; Genetics; Gene expression; RNA; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009514089,0.0002032746,0.0001862782,0.000174315,0.0001141855,0.0004747244,0.0001417964,0.0001853128,0.002452722],"category_scores_gemma":[0.0001049884,0.0001170304,0.0002117828,0.0001381085,0.0002640996,0.0001566383,0.0003063117,0.0004852176,0.0006797785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624418,"about_ca_system_score_gemma":0.0001615133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097412,"about_ca_topic_score_gemma":0.0008508887,"domain_scores_codex":[0.9998659,0.00001491213,0.00001013956,0.00004240769,0.00002725604,0.00003928652],"domain_scores_gemma":[0.9998457,0.00002160615,0.00006140936,0.00003053367,0.00001374821,0.00002702271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004556039,0.0000101453,0.0002357291,0.000007929836,0.0000017316,0.00001868515,0.000005177374,0.00002520445,0.999217,0.00008033988,0.00003436663,0.000318039],"study_design_scores_gemma":[0.000005765888,0.00007281162,0.01014838,0.000004362685,0.000006835561,0.00007255438,0.00002471019,0.0007734073,0.9875485,0.00006616795,0.001274035,0.000002541196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941983,0.000887034,0.002034446,0.000139451,0.0000350501,0.000009148127,0.0007198301,0.000198346,0.001778317],"genre_scores_gemma":[0.9960039,0.0002910148,0.0004162809,0.00005108929,0.00000572411,0.000006458509,0.0008226158,0.00004375052,0.0023592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002452722,"threshold_uncertainty_score":0.008205175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.014026467112987,"score_gpt":0.230390687414153,"score_spread":0.216364220301166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}