{"id":"W2599152940","doi":"10.1093/hmg/ddx109","title":"Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin–NFAT signaling in skeletal muscle of DM1 mice","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Biology; Hyperactivation; NFAT; Skeletal muscle; Calcineurin; Endocrinology; Cell biology; Internal medicine; Calsequestrin; SERCA; Calcium signaling; Signal transduction; Endoplasmic reticulum; Ryanodine receptor; Biochemistry; ATPase; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002420027,0.0009566967,0.0005288624,0.001036046,0.0003269843,0.0003869439,0.0004058162,0.0006578433,0.002526452],"category_scores_gemma":[0.0001710922,0.0004347078,0.0004704834,0.0003238114,0.0004332284,0.0002721899,0.0003625318,0.001174834,0.0004590842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005652555,"about_ca_system_score_gemma":0.0002284339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003334,"about_ca_topic_score_gemma":0.001551357,"domain_scores_codex":[0.999576,0.00005833478,0.00005568,0.0001400157,0.00009242837,0.00007755479],"domain_scores_gemma":[0.9994761,0.00003986982,0.0002080857,0.00002725425,0.00002624988,0.0002225393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002840811,0.00004928032,0.0003065286,0.00003915888,0.000009005144,0.0000703386,0.00002509718,0.00002508072,0.9987242,0.00004838208,0.00002113753,0.0003977031],"study_design_scores_gemma":[0.0001411233,0.00111472,0.03941895,0.00005078626,0.00008220437,0.0007821366,0.0001301395,0.00106781,0.9543682,0.0001219379,0.002701166,0.00002082267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962612,0.001185257,0.0008220153,0.0001424666,0.00003025615,0.00002493863,0.0006884336,0.0001056759,0.000739836],"genre_scores_gemma":[0.9883164,0.001511824,0.002147999,0.0001527102,0.00002596411,0.0001508088,0.001233445,0.0001027732,0.006358139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002526452,"threshold_uncertainty_score":0.008451879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02966901504629696,"score_gpt":0.303467067642496,"score_spread":0.273798052596199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}