{"id":"W2599344293","doi":"10.1200/jco.2012.30.15_suppl.tps4695","title":"A randomized, open-label, phase II study of MDV3100 alone or in combination with leuprolide and dutasteride as neoadjuvant therapy to prostatectomy in intermediate and high-risk prostate cancer.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Prostate cancer; Dutasteride; Bicalutamide; Urology; Androgen receptor; Prostatectomy; Internal medicine; Clinical endpoint; Oncology; Antiandrogen; Androgen; Endocrinology; Cancer; Cancer research; Hormone; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001686391,0.001922386,0.002877779,0.0006116696,0.0005143147,0.001364513,0.001368651,0.001974049,0.008576026],"category_scores_gemma":[0.001352902,0.001031495,0.001133875,0.000542094,0.001908069,0.001572739,0.0004855354,0.003529251,0.001752454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001060177,"about_ca_system_score_gemma":0.002169217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127433,"about_ca_topic_score_gemma":0.003373147,"domain_scores_codex":[0.9993661,0.0003242095,0.00002705104,0.0001045965,0.00005158896,0.0001264262],"domain_scores_gemma":[0.9990019,0.0001776706,0.0001540849,0.0000780341,0.00004820621,0.0005400995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9540168,0.02742695,0.0005000349,0.000270386,0.0002584755,0.00003458888,0.00004855467,0.0003247981,0.004602036,0.0001291843,0.0007498835,0.01163839],"study_design_scores_gemma":[0.8210765,0.1763588,0.0008968907,0.00001398561,0.0001016434,0.00002791201,0.00002511086,0.0003208969,0.0004044953,0.0001256046,0.000633884,0.00001417464],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781694,0.00224127,0.0009615179,0.0007868207,0.0007307424,0.01282182,0.001381416,0.000176947,0.002729827],"genre_scores_gemma":[0.9715234,0.002261698,0.002919911,0.001638072,0.0005223084,0.01313941,0.001672296,0.00003973253,0.006283118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008576026,"threshold_uncertainty_score":0.02868968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1287908155528639,"score_gpt":0.5162259652658956,"score_spread":0.3874351497130317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}