{"id":"W2599404647","doi":"10.1001/jamaneurol.2016.5349","title":"Alzheimer Disease Signature Neurodegeneration and <i>APOE</i> Genotype in Mild Cognitive Impairment With Suspected Non–Alzheimer Disease Pathophysiology","year":2017,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Lawrence Berkeley National Laboratory; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; University of California, San Diego; BioClinica; Washington University in St. Louis; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Eisai; National Institute on Aging; Alzheimer's Association; University of California, San Francisco; Technische Universität Braunschweig; Foundation for the National Institutes of Health; U.S. Department of Defense","keywords":"Neurodegeneration; Alzheimer's disease; Dementia; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Medicine; Psychology; Positron emission tomography; Magnetic resonance imaging; Internal medicine; Disease; Atrophy; Neuroscience; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001755413,0.0003310005,0.0004021169,0.0002029829,0.0003089105,0.00009711672,0.0001736903,0.0001872569,0.0001509953],"category_scores_gemma":[0.0001873217,0.0002634977,0.00007596989,0.000126865,0.0004753322,0.0002508516,0.0002236663,0.0007924089,0.00003884364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001171863,"about_ca_system_score_gemma":0.0002495807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006047873,"about_ca_topic_score_gemma":0.00006213956,"domain_scores_codex":[0.9976088,0.0003116569,0.0002673933,0.0008523338,0.0003365554,0.0006232841],"domain_scores_gemma":[0.9983271,0.0001304211,0.0001582496,0.0005224238,0.0002756459,0.0005861355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03379654,0.001140778,0.9432097,0.00005923428,0.0002612893,0.005785759,0.000135031,0.00001268542,0.006797684,0.00008815102,0.001004109,0.00770901],"study_design_scores_gemma":[0.007568029,0.002679696,0.9860277,0.00004978229,0.0007636675,0.00002966329,0.00001546321,0.001107894,0.001055262,0.0002278805,0.0002346907,0.0002403408],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848381,0.001280267,0.00002356719,0.01146879,0.0001482523,0.001614005,0.00006729965,0.00004178817,0.0005179014],"genre_scores_gemma":[0.9894328,0.0003009058,0.00003149388,0.009314582,0.0003169281,0.0002423696,0.000219666,0.00004965238,0.00009157272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0428179,"threshold_uncertainty_score":0.9999817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641795191594801,"score_gpt":0.2893362392771061,"score_spread":0.272918287361158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}