{"id":"W2599411477","doi":"10.1093/brain/awx023","title":"Is antipsychotic sensitivity in Alzheimer’s disease secondary to abnormal blood–brain barrier integrity?","year":2017,"lang":"en","type":"letter","venue":"Brain","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Antipsychotic; Blood–brain barrier; Medicine; Alzheimer's disease; Disease; Personal Integrity; Neuroscience; Psychology; Psychiatry; Pathology; Schizophrenia (object-oriented programming); Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0008356654,0.0006470805,0.0009407129,0.0006583054,0.0001754821,0.0001534555,0.0003272522,0.0005589447,0.001167638],"category_scores_gemma":[0.001134454,0.0005623227,0.000374849,0.0001987545,0.0002079665,0.0001699033,0.000215379,0.003875865,0.0008162269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001403447,"about_ca_system_score_gemma":0.001561632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008018711,"about_ca_topic_score_gemma":0.000971958,"domain_scores_codex":[0.9960404,0.0003960076,0.0004380209,0.001122584,0.0009024783,0.001100501],"domain_scores_gemma":[0.996408,0.0005756758,0.0001377572,0.001754113,0.000121328,0.001003163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003659359,0.0003090643,0.009642738,0.000190097,0.000611315,0.06310954,0.000120449,1.880667e-7,0.0000871291,0.00001338353,0.914864,0.007392727],"study_design_scores_gemma":[0.01189973,0.00112049,0.4162161,0.001458848,0.0007984499,0.0007900356,0.00002048412,0.00006207815,0.0005129886,0.0006890098,0.5653808,0.00105108],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1074245,0.001072431,0.00001089082,0.8867927,0.0003767107,0.001679775,0.00106416,0.00007858141,0.001500279],"genre_scores_gemma":[0.1969466,0.00003237164,0.0007115843,0.7873852,0.003432307,0.0001961252,0.001159274,0.000147899,0.009988617],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.4065734,"threshold_uncertainty_score":0.9999617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04197409716764519,"score_gpt":0.3331329955190932,"score_spread":0.291158898351448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}