{"id":"W2599451377","doi":"10.1200/jco.2013.31.15_suppl.1552","title":"Genome sequencing of multiple primary tumors to reveal underlying germline cancer susceptibility.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"PALB2; Sanger sequencing; Germline; Genetics; Ovarian cancer; Germline mutation; Biology; Breast cancer; Cancer; Medicine; DNA sequencing; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000184078,0.0003013019,0.0002381813,0.0006202488,0.0002765057,0.0002395326,0.0001979574,0.0004402062,0.00364022],"category_scores_gemma":[0.0004419561,0.0001642575,0.0002846379,0.0004358667,0.00009146932,0.00006483152,0.0001847352,0.0003089684,0.0008141552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004145346,"about_ca_system_score_gemma":0.0002639473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004072425,"about_ca_topic_score_gemma":0.01258788,"domain_scores_codex":[0.9998792,0.00001112808,0.000009254546,0.0000401652,0.00003753285,0.0000226172],"domain_scores_gemma":[0.9998181,0.00004618847,0.00003241216,0.00002188716,0.00004754122,0.00003378064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007524803,0.0001787228,0.2263375,0.000375516,0.0003688904,0.01044751,0.0006617411,0.0007886629,0.6774788,0.0005360415,0.00467564,0.07739852],"study_design_scores_gemma":[0.0001550036,0.0007620564,0.8055476,0.0001167741,0.0004764495,0.03582469,0.0003547371,0.005469829,0.1058307,0.0007243009,0.04471145,0.00002628848],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820967,0.001229257,0.005569168,0.0002413916,0.00005959819,0.000116966,0.006326422,0.0002317405,0.004128819],"genre_scores_gemma":[0.9759051,0.0006197544,0.00901625,0.0003370138,0.00003018989,0.00005059506,0.009444211,0.00006280105,0.004534036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004072425,"threshold_uncertainty_score":0.01217782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1231061167253051,"score_gpt":0.4392346748890833,"score_spread":0.3161285581637782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}