{"id":"W2599797030","doi":"10.1038/srep45038","title":"PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Université de Moncton; Dalhousie University; University of New Brunswick; Beatrice Hunter Cancer Research Institute; Atlantic Cancer Research Institute; Nova Scotia Health Authority","funders":"National Human Genome Research Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Defense Science and Engineering Graduate; Terry Fox Foundation; Beatrice Hunter Cancer Research Institute; National Institutes of Health; Edward Mallinckrodt, Jr. Foundation; National Institute of Mental Health; Cancer Research Institute","keywords":"PI3K/AKT/mTOR pathway; Promyelocytic leukemia protein; Gene silencing; Cancer research; Biology; Cell biology; Gene; Nuclear protein; Signal transduction; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000794966,0.0001067975,0.0001117672,0.00001607936,0.001051012,0.0002451272,0.0006015397,0.00008671819,0.00002914374],"category_scores_gemma":[0.0009366252,0.00005760679,0.0001167093,0.00004202539,0.0004667137,0.000008351725,0.0005887222,0.00007694904,0.000009510407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000101701,"about_ca_system_score_gemma":0.0001295183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001304111,"about_ca_topic_score_gemma":0.00001684424,"domain_scores_codex":[0.9987262,0.0000440526,0.0002648406,0.000434298,0.0003290135,0.0002016156],"domain_scores_gemma":[0.9974745,0.000007472631,0.0003777063,0.001875463,0.0002035283,0.00006135803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001457783,0.00001654149,0.001888621,0.00001394937,0.00000718044,0.000007957426,0.0001159609,0.00001113371,0.8835967,0.00001545215,0.1140509,0.0002610535],"study_design_scores_gemma":[0.0000570725,0.00002146714,0.001061979,0.0000332953,0.000007194275,0.00001577841,0.0000441991,0.000003734453,0.6896432,0.0002895373,0.3087607,0.00006183156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907469,0.000267905,0.00007289308,0.0007704121,0.005606259,0.0002453509,0.000009213645,0.000006873719,0.002274232],"genre_scores_gemma":[0.9924861,0.00001053219,0.0001100455,0.0000948309,0.0003286685,0.00001325703,0.00001281115,0.00001232994,0.00693143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1947098,"threshold_uncertainty_score":0.8083638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008177008140039814,"score_gpt":0.2396493891878064,"score_spread":0.2314723810477665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}