{"id":"W2599800000","doi":"10.1093/ndt/gfw219","title":"When is a meta-analysis conclusive? A guide to Trial Sequential Analysis with an example of remote ischemic preconditioning for renoprotection in patients undergoing cardiac surgery","year":2017,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; Western University; Population Health Research Institute; London Health Sciences Centre; McMaster University","funders":"","keywords":"Medicine; Relative risk; Confidence interval; Randomized controlled trial; Acute kidney injury; Meta-analysis; Dialysis; Cardiac surgery; Clinical trial; Sample size determination; Surgery; Internal medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001609344,0.0002612075,0.002106615,0.001984399,0.0003133086,0.00006147192,0.0002026747,0.0002524574,0.0003089942],"category_scores_gemma":[0.0002731348,0.0002326926,0.001532821,0.001030294,0.0001292448,0.0004347548,0.00002339471,0.0001887771,0.000002899576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001430831,"about_ca_system_score_gemma":0.0002882025,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00749252,"about_ca_topic_score_gemma":0.008034405,"domain_scores_codex":[0.9969243,0.000430599,0.0009076598,0.0007888049,0.0005601356,0.0003885357],"domain_scores_gemma":[0.997133,0.0005463519,0.0006640602,0.0009159183,0.0005508895,0.000189744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1964462,0.0006661364,0.1466119,0.0004247614,0.6271263,0.00002393589,0.009229113,0.001523338,0.01229318,0.0000124855,0.00215404,0.003488605],"study_design_scores_gemma":[0.02789689,0.003013336,0.08576217,0.00002347305,0.8554619,0.000003370797,0.0001212454,0.003151755,0.02350195,0.0001363681,0.0004708528,0.0004567263],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9200926,0.00001668491,0.0761483,0.0006969454,0.00004950304,0.002051745,0.0008006009,0.00002792161,0.0001157004],"genre_scores_gemma":[0.9834986,0.00003465628,0.01075947,0.0003563075,0.000106835,0.0004854702,0.004609854,0.00003078905,0.0001179828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2283356,"threshold_uncertainty_score":0.9991167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07496024548367157,"score_gpt":0.352791315816027,"score_spread":0.2778310703323554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}