{"id":"W2599998987","doi":"10.1021/acsinfecdis.7b00019","title":"An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall","year":2017,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Daptomycin; Lipopeptide; Dimer; Bacillus subtilis; Bacterial cell structure; Microbiology; Staphylococcus aureus; Cell wall; Membrane; Cell membrane; Chemistry; Bacteria; Biology; Biochemistry; Vancomycin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008603149,0.0001933794,0.0001985795,0.00007899742,0.00008743285,0.0002033422,0.0001220531,0.0001804941,0.0005760394],"category_scores_gemma":[0.0001511311,0.00009683926,0.00009037687,0.0001102002,0.0001124757,0.0001123085,0.0001566231,0.0004288173,0.000183844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935585,"about_ca_system_score_gemma":0.0001112157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003087513,"about_ca_topic_score_gemma":0.0003476441,"domain_scores_codex":[0.9998549,0.00003616795,0.00001364813,0.00002859053,0.00003818305,0.00002846606],"domain_scores_gemma":[0.9999003,0.00001586431,0.00002483229,0.000009402509,0.00001189041,0.00003761294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006740962,0.00001191072,0.0001492672,0.000008589704,0.000002523832,0.00002222813,0.000004711259,0.00002989245,0.9994425,0.00002057013,0.00001197961,0.0002284343],"study_design_scores_gemma":[0.00001408991,0.0001714545,0.002301948,0.000003166324,0.000006733245,0.0001948869,0.00001976928,0.001052261,0.9950112,0.00001873175,0.001202954,0.000002770707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980882,0.0002864069,0.0009756277,0.00003297547,0.000008938918,0.000009245063,0.00006689448,0.000008589917,0.0005232146],"genre_scores_gemma":[0.9972817,0.0001220332,0.001018989,0.00002923681,0.00000315881,0.000009710049,0.0002750716,0.000009143138,0.001250953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005760394,"threshold_uncertainty_score":0.001927078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008713365676768633,"score_gpt":0.2397417292112732,"score_spread":0.2310283635345045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}