{"id":"W2600015730","doi":"10.1161/atvbaha.117.309138","title":"Microvascular Endothelial Dysfunction in Obesity Is Driven by Macrophage-Dependent Hydrogen Sulfide Depletion","year":2017,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"Canadian Institutes of Health Research; Rosalind Franklin University of Medicine and Science","keywords":"Adipose tissue; Proinflammatory cytokine; Endocrinology; Electrical impedance myography; Internal medicine; Vasodilation; Adipose tissue macrophages; Nitric oxide synthase; Nitric oxide; Macrophage; Inflammation; Endothelial dysfunction; Chemistry; Medicine; White adipose tissue; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446584,0.0003273676,0.0002207806,0.0002266586,0.000116409,0.0002211113,0.0001144693,0.0002073532,0.0008283727],"category_scores_gemma":[0.0002076883,0.0001755583,0.000189807,0.0001316548,0.0002680447,0.0001392428,0.0002563296,0.0006148964,0.0001179411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000133119,"about_ca_system_score_gemma":0.000109935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001636241,"about_ca_topic_score_gemma":0.0003298428,"domain_scores_codex":[0.9998884,0.00002981261,0.000008700167,0.00002057746,0.00002998037,0.00002247811],"domain_scores_gemma":[0.9998164,0.00002007344,0.00008567783,0.00001662909,0.00001574005,0.00004547747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004684931,0.00006739834,0.001824079,0.00004862842,0.00001446813,0.0003725919,0.00002061944,0.00006468697,0.9949733,0.0001677024,0.00007575841,0.001902242],"study_design_scores_gemma":[0.0001934091,0.00302222,0.1622408,0.00008351385,0.0001830223,0.008407087,0.0002274103,0.003295709,0.817648,0.0008372346,0.003831467,0.00003009232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958371,0.0008024697,0.002522606,0.0001275771,0.00002414087,0.00001186494,0.00007709511,0.00005351556,0.0005437409],"genre_scores_gemma":[0.9973382,0.0006932124,0.001120748,0.00007434722,0.00001950395,0.00002131081,0.00007647731,0.00001083628,0.0006453453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008283727,"threshold_uncertainty_score":0.002771199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852576155840961,"score_gpt":0.2627893849952745,"score_spread":0.2442636234368649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}