{"id":"W2600099876","doi":"10.1200/jco.2014.32.15_suppl.10056","title":"Complete radiographic responses in pediatric patients with <i>BRAF</i><sup>V600</sup>-positive tumors including high-grade gliomas: Preliminary results of an ongoing phase 1/2a safety and pharmacokinetics (PK) study of dabrafenib.","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Dabrafenib; Trametinib; Internal medicine; Phases of clinical research; Pharmacokinetics; Anaplastic astrocytoma; Progressive disease; Anaplastic thyroid cancer; Oncology; Cancer; Gastroenterology; Glioma; Chemotherapy; Astrocytoma; Cancer research; Kinase; Thyroid cancer; Vemurafenib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004672828,0.0004169424,0.000703507,0.0001651599,0.0001815041,0.0002702121,0.0002411148,0.0002757472,0.001358129],"category_scores_gemma":[0.0005444125,0.0001845388,0.0004331019,0.0002670046,0.000228029,0.0002781057,0.0001678914,0.001009162,0.0003299268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006079227,"about_ca_system_score_gemma":0.0007495775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432732,"about_ca_topic_score_gemma":0.003466916,"domain_scores_codex":[0.9998164,0.00007254718,0.00001302733,0.00002944631,0.00003447067,0.00003417832],"domain_scores_gemma":[0.9995611,0.00008172802,0.000158709,0.00002708963,0.00004241596,0.0001288578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08868237,0.01448853,0.227088,0.001480948,0.001119283,0.002913404,0.000809426,0.007087195,0.2158175,0.0002642634,0.0112723,0.4289769],"study_design_scores_gemma":[0.02235569,0.3118975,0.5826245,0.0001138838,0.0007760298,0.01193005,0.0003612521,0.002892966,0.05152313,0.0002111908,0.01526853,0.00004529385],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931531,0.003252295,0.0009851013,0.0001503289,0.00001164773,0.0003228746,0.0007906436,0.00006134986,0.00127273],"genre_scores_gemma":[0.9941211,0.00199498,0.001528392,0.0001793684,0.00002300601,0.0002478267,0.001468248,0.00001899351,0.0004180844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432732,"threshold_uncertainty_score":0.004543364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06140223544629098,"score_gpt":0.4056580172350463,"score_spread":0.3442557817887553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}