{"id":"W2600126358","doi":"10.1101/cshperspect.a024067","title":"Structural and Chemical Biology of Presenilin Complexes","year":2017,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Alzheimer Society; Wellcome Trust","keywords":"Presenilin; Allosteric regulation; Nicastrin; Structural biology; Transmembrane protein; Transmembrane domain; Chemistry; Active site; Proteases; Biochemistry; Enzyme; Stereochemistry; Biophysics; Biology; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002487142,0.0003970862,0.002535724,0.0003971179,0.00006577827,0.000009356924,0.0002717637,0.0002401834,0.00009240409],"category_scores_gemma":[0.0008632986,0.0002716635,0.0001990371,0.0001479058,0.001553971,0.00004692363,0.0002083914,0.0005587925,0.000004399517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117673,"about_ca_system_score_gemma":0.0003381046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002331307,"about_ca_topic_score_gemma":0.000004587411,"domain_scores_codex":[0.9980564,0.0001213668,0.0005247226,0.0006215493,0.0002857081,0.0003902236],"domain_scores_gemma":[0.9982657,0.0002974465,0.0003021148,0.0006954954,0.0001305443,0.0003086507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001868638,0.002292049,0.04196885,0.1280294,0.06195937,0.003521556,0.002967923,2.402287e-7,0.001558138,0.1357718,0.000460323,0.6196017],"study_design_scores_gemma":[0.03007886,0.004981497,0.05578365,0.2083456,0.02469743,0.0002580207,0.001447388,0.0002033009,0.0005277379,0.001103913,0.6696539,0.002918727],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004573407,0.9935267,0.000001422709,0.0001240729,0.00007472497,0.001163869,0.0000445082,0.00002519931,0.0004661257],"genre_scores_gemma":[0.1039471,0.8953875,0.0001924832,0.00000454137,0.0003294176,0.00006774377,0.00001405962,0.00004044911,0.00001670674],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6691936,"threshold_uncertainty_score":0.9999735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1305306213430026,"score_gpt":0.440754813944525,"score_spread":0.3102241926015225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}