{"id":"W2600246255","doi":"10.1038/boneres.2017.8","title":"Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis","year":2017,"lang":"en","type":"article","venue":"Bone Research","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Johns Hopkins University","keywords":"Cell biology; Integrin; Intervertebral disc; Homeostasis; Transforming growth factor; Signal transduction; Chemistry; Transforming growth factor beta; Receptor; Medicine; Anatomy; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009450635,0.0001029611,0.0003230843,0.0003334739,0.0002543922,0.00004554529,0.0002699492,0.0001118734,0.0007474351],"category_scores_gemma":[0.001203002,0.0000831726,0.0001581469,0.0001223314,0.0002762467,0.0002274106,0.0003229721,0.0003848229,0.0000857243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008675786,"about_ca_system_score_gemma":0.0001068123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005218842,"about_ca_topic_score_gemma":0.00002953996,"domain_scores_codex":[0.9984362,0.0001203236,0.0002854159,0.0002616622,0.0005009297,0.0003954308],"domain_scores_gemma":[0.9986917,0.00002337847,0.0001134109,0.0007131358,0.0003335973,0.0001247778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003939087,0.000708409,0.01012718,0.0004788736,0.000187776,0.0002219678,0.0006578306,0.000001002218,0.8580862,0.01567576,0.01175669,0.1017044],"study_design_scores_gemma":[0.002249145,0.001969207,0.307468,0.0008540262,0.00003762781,0.00006735115,0.001146167,0.001009161,0.6817295,0.002742499,0.0005565716,0.0001707577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799336,0.0001352439,0.001497116,0.004658197,0.00007908262,0.0003419009,0.00001182188,0.00002431697,0.01331875],"genre_scores_gemma":[0.9973161,0.00005877036,0.0005537646,0.00008142759,0.0001258173,0.00002951154,0.00002134995,0.00002134543,0.001791967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2973408,"threshold_uncertainty_score":0.8183891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1910837320958758,"score_gpt":0.4626813421283889,"score_spread":0.271597610032513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}