{"id":"W2600246255","doi":"10.1038/boneres.2017.8","title":"Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis","year":2017,"lang":"en","type":"article","venue":"Bone Research","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Johns Hopkins University","keywords":"Cell biology; Integrin; Intervertebral disc; Homeostasis; Transforming growth factor; Signal transduction; Chemistry; Transforming growth factor beta; Receptor; Medicine; Anatomy; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000980246,0.0002191508,0.000174803,0.000156119,0.0001496498,0.0003008902,0.0001591897,0.0002121641,0.0007624864],"category_scores_gemma":[0.00008991208,0.00007274222,0.0001322048,0.00007918356,0.0002183884,0.000146211,0.0001452891,0.000361073,0.0002393206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001742782,"about_ca_system_score_gemma":0.0001716519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002796348,"about_ca_topic_score_gemma":0.0004564014,"domain_scores_codex":[0.9999117,0.00001615058,0.00000690941,0.00001356768,0.00002313527,0.00002861692],"domain_scores_gemma":[0.999911,0.000008003272,0.00003645405,0.00001012457,0.00001447121,0.00002003135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005381962,0.00001439018,0.0003473426,0.00002646111,0.000002399016,0.00004893733,0.000008132075,0.00001804272,0.9979971,0.00008023062,0.00002356031,0.001379638],"study_design_scores_gemma":[0.00005470329,0.0007276085,0.02464513,0.00003690557,0.00003371375,0.0008109538,0.0001397812,0.0008733563,0.9671342,0.0002732229,0.005265074,0.000005391648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893529,0.005280814,0.002502454,0.0001905242,0.0000689345,0.00001688396,0.0001012981,0.00006278317,0.002423455],"genre_scores_gemma":[0.9968868,0.00129578,0.0007110882,0.00004193262,0.00001782434,0.00001170772,0.00005829686,0.000004222338,0.0009723767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007624864,"threshold_uncertainty_score":0.002550781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1910837320958758,"score_gpt":0.4626813421283889,"score_spread":0.271597610032513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}