{"id":"W2600306685","doi":"10.1200/jco.2017.35.6_suppl.498","title":"Fourth-line targeted therapy in metastatic renal cell carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Baker Hughes (Canada)","funders":"","keywords":"Medicine; Sorafenib; Sunitinib; Pazopanib; Everolimus; Targeted therapy; Axitinib; Internal medicine; Temsirolimus; Oncology; Renal cell carcinoma; Nivolumab; Cancer; Hepatocellular carcinoma; Immunotherapy; Discovery and development of mTOR inhibitors; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003567316,0.0002213415,0.0005440053,0.002391616,0.000221003,0.0009141393,0.0005727747,0.0003571199,0.001684861],"category_scores_gemma":[0.0070203,0.0001329405,0.0005529568,0.004841785,0.0001703423,0.000503125,0.0008073747,0.0003139587,0.0005201378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009121795,"about_ca_system_score_gemma":0.001044485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01583121,"about_ca_topic_score_gemma":0.01785881,"domain_scores_codex":[0.9977469,0.0006956751,0.0003666641,0.0003207866,0.000717387,0.0001526528],"domain_scores_gemma":[0.9902001,0.002656561,0.004026403,0.0008462548,0.001398044,0.0008725992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001101466,0.00007057758,0.9728549,0.0003704624,0.0004208759,0.00008350506,0.00009848135,0.0003713253,0.0001601088,0.00007596989,0.008870158,0.01552221],"study_design_scores_gemma":[0.0002121654,0.0001872271,0.9895296,0.000128144,0.0003746359,0.0003779773,0.0001482021,0.001306938,0.0003117756,0.00003382022,0.007372936,0.00001669955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8205828,0.006046447,0.0004393748,0.0006414826,0.00002609452,0.0001843464,0.1693057,0.00005920488,0.002714511],"genre_scores_gemma":[0.8432309,0.001664669,0.000818243,0.0002177515,0.00004221503,0.0001090136,0.1534684,0.00001975581,0.0004289552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01583121,"threshold_uncertainty_score":0.03147811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2193807385605218,"score_gpt":0.4479544508668474,"score_spread":0.2285737123063256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}