{"id":"W2600339997","doi":"10.3390/md15030083","title":"An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35","year":2017,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Vancouver Coastal Health; Dalhousie University","funders":"Instituto de Física de Cantabria; Guangdong Ocean University; National Natural Science Foundation of China","keywords":"SH-SY5Y; Viability assay; Nerve growth factor; Tropomyosin receptor kinase B; Neurotoxicity; Chemistry; Apoptosis; Nitric oxide; Brain-derived neurotrophic factor; Reactive oxygen species; Oxidative stress; Biology; Molecular biology; Neurotrophic factors; Biochemistry; Endocrinology; Receptor; Cell culture; Neuroblastoma; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001491361,0.0002921389,0.0002388867,0.00002435073,0.0003781537,0.0002281709,0.0009672323,0.0002761703,0.0001457023],"category_scores_gemma":[0.0001628577,0.0002843796,0.00005823669,0.00007822344,0.0001818053,0.00002489469,0.000546505,0.0002823469,0.0000375916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002234583,"about_ca_system_score_gemma":0.0001148751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002813439,"about_ca_topic_score_gemma":0.00009553683,"domain_scores_codex":[0.9980295,0.00005935438,0.0002930454,0.0009830862,0.0002670276,0.0003679478],"domain_scores_gemma":[0.997788,0.00001542789,0.0002941689,0.001565073,0.00008381964,0.0002535782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004333851,0.0002795967,0.0005379886,0.000014973,0.00001672005,0.000001985542,0.00004668048,1.9164e-7,0.9239542,0.000001122463,0.005802798,0.06930038],"study_design_scores_gemma":[0.0005445104,0.0001064376,0.006163689,0.00001220426,0.00001988004,8.574358e-7,0.00001807507,0.0001278123,0.9164731,0.000192802,0.07602238,0.00031825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955829,0.0001103637,0.0006758156,0.001368265,0.0001457393,0.0007224603,0.0004270142,0.00005440041,0.0009129993],"genre_scores_gemma":[0.9948211,0.00002407935,0.001218827,0.0004360419,0.0006966873,0.000192177,0.002023121,0.0000538645,0.0005340581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07021958,"threshold_uncertainty_score":0.9999608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101805118781312,"score_gpt":0.2658659645291306,"score_spread":0.2548479133413175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}