{"id":"W2600400434","doi":"10.1016/j.ymthe.2017.03.013","title":"Lipid Nanoparticle Systems for Enabling Gene Therapies","year":2017,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada); University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; National Research Council Canada; Medical Research Council Canada; Canadian Institutes of Health Research; Genome British Columbia; Alnylam Pharmaceuticals","keywords":"Gene silencing; Genetic enhancement; RNA interference; Small interfering RNA; Computational biology; Genome editing; Gene; Gene delivery; Biology; Bioinformatics; Medicine; RNA; CRISPR; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002807049,0.0004549236,0.0008750238,0.00007375462,0.0001936704,0.0002035182,0.0007275004,0.0004242766,0.000007787216],"category_scores_gemma":[0.00003742209,0.000365144,0.000735549,0.00004468875,0.00006825346,0.000004735881,0.00008380933,0.0001139387,0.00003912121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001890705,"about_ca_system_score_gemma":0.0001772418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001651563,"about_ca_topic_score_gemma":0.000001447729,"domain_scores_codex":[0.9982846,0.0001379348,0.000414726,0.0006228717,0.0001380691,0.0004017729],"domain_scores_gemma":[0.9982871,0.00001677989,0.0003478902,0.001134026,0.0001319633,0.00008219346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000586432,0.00006337162,0.000001311801,0.001044709,0.0009274231,0.00001273165,0.00002663935,0.000009344291,0.09187062,0.00005221735,0.0008941037,0.9050389],"study_design_scores_gemma":[0.000373477,0.0003965398,1.753901e-7,0.0007134928,0.0001069852,0.00002811409,0.000009635624,0.000006579628,0.03282915,0.00001551997,0.9650909,0.0004294911],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002068695,0.9944537,0.001479377,0.00001725524,0.0006372591,0.001141097,0.00007535102,0.00002072113,0.0001065178],"genre_scores_gemma":[0.0007861778,0.9957529,0.0001185945,0.0001244143,0.0007337232,0.0006350829,0.0003742216,0.0001184741,0.001356372],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9641967,"threshold_uncertainty_score":0.9998801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09359412117780753,"score_gpt":0.3576907772856159,"score_spread":0.2640966561078084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}