{"id":"W2600454075","doi":"10.1136/jclinpath-2017-204381","title":"Effect of fixation time on breast biomarker expression: a controlled study using cell line-derived xenografted (CDX) tumours","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; St. John’s Health Sciences Centre; University Health Network; Memorial University of Newfoundland","funders":"Newfoundland and Labrador Centre for Applied Health Research","keywords":"Immunohistochemistry; Fixative; Breast cancer; Fixation (population genetics); Staining; Biomarker; Pathology; Medicine; Fixation time; Biology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001878998,0.0002121809,0.00108631,0.00007216021,0.0001468679,0.00001735806,0.0003019559,0.0002243634,0.00001929338],"category_scores_gemma":[0.001376495,0.0001394249,0.0004751029,0.00003022927,0.0002489807,0.000009314067,0.0001519271,0.0002060019,0.00000535177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001414711,"about_ca_system_score_gemma":0.00008210292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005615245,"about_ca_topic_score_gemma":0.000003037223,"domain_scores_codex":[0.9971623,0.00109342,0.001081232,0.0002742919,0.0002043113,0.0001844675],"domain_scores_gemma":[0.9964545,0.0004010769,0.002267291,0.0004810085,0.0002958738,0.000100205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04462506,0.002205786,0.2468118,0.00002625003,0.0005480704,0.0002980188,0.00008110791,0.00006818725,0.698658,2.93941e-7,0.0003340502,0.006343409],"study_design_scores_gemma":[0.05496607,0.01686344,0.8000473,0.000157233,0.0008255057,0.0003669267,0.00007210985,0.0001075975,0.1262874,0.00001623079,0.00004550321,0.0002446385],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998435,0.0002059986,0.0001022119,0.0002054712,0.0005184658,0.000355325,0.00001792502,0.000003612431,0.0001560152],"genre_scores_gemma":[0.9990562,0.00005033422,0.0002594467,0.00006105062,0.0005010537,0.000008285041,0.000005183151,0.00001980874,0.00003869404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5723705,"threshold_uncertainty_score":0.5685582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0360375413733905,"score_gpt":0.396977766616691,"score_spread":0.3609402252433005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}