{"id":"W2600508787","doi":"10.1038/s41598-017-00275-9","title":"Bilirubin augments Ca2+ load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; Hospital for Sick Children; University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Calcium; Voltage-dependent calcium channel; EGTA; T-type calcium channel; Neurotoxicity; Calcium in biology; Patch clamp; Calmodulin; Chemistry; Endocrinology; Internal medicine; Biophysics; Bilirubin; Intracellular; Neuroscience; Biology; Cell biology; Medicine; Electrophysiology; Biochemistry; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054747,0.0002814361,0.0003581547,0.0001789397,0.0001048681,0.0002283936,0.000233723,0.0002245827,0.00140389],"category_scores_gemma":[0.0002180018,0.0001188647,0.0001731725,0.0001060375,0.0002756818,0.0003103846,0.0002333898,0.000576203,0.0001559544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754829,"about_ca_system_score_gemma":0.0002307594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086628,"about_ca_topic_score_gemma":0.001579911,"domain_scores_codex":[0.9999205,0.000007543149,0.00001066401,0.00001696912,0.00001919102,0.00002519544],"domain_scores_gemma":[0.9998648,0.00001899585,0.00004236601,0.00001163268,0.00002439278,0.00003775103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000148669,0.00001128529,0.0003342769,0.00004744796,0.00000366291,0.00008518288,0.00001931699,0.00001291572,0.9982862,0.0000276378,0.00001930935,0.001003974],"study_design_scores_gemma":[0.00001729702,0.0006636992,0.01474189,0.00001183666,0.00002260645,0.0002565907,0.00009633719,0.000402576,0.9826822,0.00007569581,0.001025229,0.00000406316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962566,0.001300279,0.001417335,0.00007856415,0.00003352496,0.00001988073,0.0001557634,0.00006829347,0.000669851],"genre_scores_gemma":[0.9951428,0.0009811899,0.001510078,0.00007709325,0.000009219917,0.00004434893,0.0001773,0.0000227453,0.002035219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00140389,"threshold_uncertainty_score":0.004696488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03567474915956517,"score_gpt":0.3092698322192564,"score_spread":0.2735950830596912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}