{"id":"W2600546946","doi":"10.18632/oncotarget.16646","title":"Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Stem Cell Network; Canadian Imperial Bank of Commerce; Breast Cancer Research Foundation","keywords":"Breast cancer; Medicine; Serotonergic; Population; Cancer; Internal medicine; Oncology; Cancer research; Chemotherapy; Metastatic breast cancer; Pharmacology; Serotonin; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009522876,0.0002780606,0.0003389473,0.0002325744,0.00009123559,0.0002050462,0.0002293862,0.0001750271,0.001646048],"category_scores_gemma":[0.00007727739,0.00009536197,0.0001834782,0.0001542023,0.00009376154,0.0001195734,0.0001027685,0.0004960274,0.0006243665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952377,"about_ca_system_score_gemma":0.0002116197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006118591,"about_ca_topic_score_gemma":0.003367089,"domain_scores_codex":[0.9999191,0.00001140386,0.000007982604,0.000007699377,0.00003016254,0.00002367029],"domain_scores_gemma":[0.9999348,0.00001795241,0.0000157819,0.000006618041,0.000008083253,0.00001673891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007499681,0.0004965574,0.0005581875,0.0001113309,0.00003498737,0.0001104993,0.00002773047,0.000424941,0.9776483,0.0001263151,0.001062172,0.01864917],"study_design_scores_gemma":[0.0004749889,0.009916159,0.01676109,0.00003117482,0.0001194384,0.0007383453,0.00008426279,0.003200803,0.9577338,0.0001039388,0.01082294,0.00001315948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841488,0.006852215,0.001169419,0.0003315163,0.0001205495,0.0001179013,0.0005859716,0.0001583584,0.006515268],"genre_scores_gemma":[0.988407,0.005304509,0.001163065,0.0001519403,0.00004012735,0.00006791386,0.0009525197,0.00002769232,0.003885181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001646048,"threshold_uncertainty_score":0.005506575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055275776241511,"score_gpt":0.2676192176211476,"score_spread":0.2570664598587325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}