{"id":"W2600741732","doi":"10.1177/1078155217701293","title":"Clinical impact and management of fluconazole discontinuation on sirolimus levels in bone marrow transplant patients","year":2017,"lang":"en","type":"article","venue":"Journal of Oncology Pharmacy Practice","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Alberta Health Services","funders":"","keywords":"Sirolimus; Medicine; Fluconazole; Discontinuation; CYP3A4; Pharmacology; Internal medicine; Gastroenterology; Metabolism; Cytochrome P450; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002562377,0.0001244972,0.000535213,0.0001490006,0.00005921567,0.00001642537,0.0001150232,0.00008102784,0.00005133474],"category_scores_gemma":[0.0003140209,0.00009669668,0.0001195394,0.00004252369,0.00009643914,0.0005470729,0.0000182105,0.0004722681,0.000005780418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113302,"about_ca_system_score_gemma":0.0001486779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001992767,"about_ca_topic_score_gemma":0.000004099138,"domain_scores_codex":[0.9979473,0.0003301442,0.001048107,0.0001458542,0.0003518255,0.0001767411],"domain_scores_gemma":[0.9970009,0.0008394087,0.001620457,0.0001783801,0.0002063697,0.0001544224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02008508,0.005422272,0.8018394,0.0005011121,0.0008760453,0.003392502,0.001346589,0.00002654969,0.004382044,0.00008167959,0.0002993688,0.1617474],"study_design_scores_gemma":[0.02684916,0.002510451,0.9614898,0.0006153373,0.001050851,0.0008719547,0.0001638786,0.0001470757,0.001919021,0.00002169615,0.004273545,0.00008721347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901296,0.0001549266,0.0001391648,0.003412024,0.0003977826,0.0003854081,0.000013917,0.000002828108,0.005364387],"genre_scores_gemma":[0.9939228,0.003481595,0.002112182,0.0003263722,0.00009485201,0.00000347565,0.00000473438,0.00001216297,0.00004180861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1616602,"threshold_uncertainty_score":0.3943176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09453958013113745,"score_gpt":0.4771475030205394,"score_spread":0.382607922889402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}