{"id":"W2600787820","doi":"10.1038/srep44841","title":"Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; University of California, Davis; University of Manitoba; Research Manitoba; Mitacs","keywords":"Simvastatin; Prenylation; Programmed cell death; Apoptosis; RHOA; Cancer research; A549 cell; RAC1; Lovastatin; Cell culture; Biology; Chemistry; HMG-CoA reductase; Cancer cell; Geranylgeranylation; Cell biology; Pharmacology; Signal transduction; Biochemistry; Cancer; Cholesterol; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169041,0.0003093415,0.000424209,0.0002490508,0.0001630847,0.0001939735,0.000159281,0.0001849245,0.001055992],"category_scores_gemma":[0.00007697335,0.0001059217,0.0003268995,0.0002053152,0.0001390045,0.0001764444,0.0001681506,0.0005319856,0.0003141263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002477248,"about_ca_system_score_gemma":0.0003036081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009236574,"about_ca_topic_score_gemma":0.001363066,"domain_scores_codex":[0.999856,0.0000240635,0.00002204883,0.00001943454,0.00003096546,0.00004745731],"domain_scores_gemma":[0.9999508,0.000008468857,0.000009509831,0.000008300747,0.000008958127,0.00001397731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003596256,0.00007017455,0.000243399,0.00005098214,0.00001305361,0.00005086315,0.00002573594,0.00006442595,0.9969633,0.00009382945,0.00006489405,0.001999554],"study_design_scores_gemma":[0.00003933057,0.0006752974,0.003623779,0.000004922591,0.00002006913,0.0001525109,0.00002835659,0.0008685229,0.9926538,0.00004987422,0.001880344,0.000003185495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928503,0.002368045,0.00233654,0.0001189372,0.0000295693,0.00004922301,0.0004840471,0.000112339,0.001651004],"genre_scores_gemma":[0.9942021,0.001438518,0.001605408,0.00005332857,0.00001038379,0.00007184499,0.0009368222,0.00001491793,0.001666555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055992,"threshold_uncertainty_score":0.003532648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00867390445071989,"score_gpt":0.236119608492193,"score_spread":0.2274457040414731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}