{"id":"W2600787820","doi":"10.1038/srep44841","title":"Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; University of California, Davis; University of Manitoba; Research Manitoba; Mitacs","keywords":"Simvastatin; Prenylation; Programmed cell death; Apoptosis; RHOA; Cancer research; A549 cell; RAC1; Lovastatin; Cell culture; Biology; Chemistry; HMG-CoA reductase; Cancer cell; Geranylgeranylation; Cell biology; Pharmacology; Signal transduction; Biochemistry; Cancer; Cholesterol; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001124392,0.0001299824,0.000169093,0.00006826217,0.0003156734,0.000131437,0.0001768725,0.0000859666,0.00001695136],"category_scores_gemma":[0.000153774,0.0001018311,0.00008848766,0.0001047845,0.0003881047,0.00001804337,0.0001358319,0.00009910919,0.000003008796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001688066,"about_ca_system_score_gemma":0.0001274422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003883091,"about_ca_topic_score_gemma":0.000291188,"domain_scores_codex":[0.998476,0.00006861795,0.0004249348,0.0005190809,0.0002821918,0.0002291234],"domain_scores_gemma":[0.9983554,0.000007522877,0.0005497499,0.0009048966,0.0001255062,0.00005694485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001618334,0.00004714818,0.000463045,0.0000163933,0.000008032904,9.226947e-7,0.0001376726,0.00001655545,0.9660413,0.000007998041,0.02800509,0.005239641],"study_design_scores_gemma":[0.0001795268,0.00002814591,0.001418886,0.00002125823,0.000008100198,0.00002072523,0.0000594725,0.000006632788,0.8672431,0.000380192,0.1305247,0.0001093389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837783,0.0005053941,0.0001169264,0.0001299782,0.01484396,0.0002645294,0.00002522024,0.000006188415,0.0003295202],"genre_scores_gemma":[0.9980645,0.00005683329,0.00008495669,0.00004456672,0.000752977,0.00002991852,0.0001551274,0.00001324489,0.0007979228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1025196,"threshold_uncertainty_score":0.4152554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00867390445071989,"score_gpt":0.236119608492193,"score_spread":0.2274457040414731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}