{"id":"W2600935377","doi":"10.1126/scisignal.aah5756","title":"Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation","year":2017,"lang":"en","type":"article","venue":"Science Signaling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemokine receptor; Receptor; CCR1; Cell biology; Chemokine; G protein-coupled receptor; C-C chemokine receptor type 7; Biology; CCL21; C-C chemokine receptor type 6; Chemokine receptor CCR5; Computational biology; Chemistry; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154419,0.0003704867,0.0003451578,0.0001527546,0.0005124427,0.0004680862,0.0009170019,0.0008143976,0.001684416],"category_scores_gemma":[0.0002354353,0.0002305485,0.0003623494,0.000150603,0.000755451,0.0004824819,0.0002623371,0.0009162282,0.0007017426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007215257,"about_ca_system_score_gemma":0.0005094971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007688089,"about_ca_topic_score_gemma":0.0005939348,"domain_scores_codex":[0.9998746,0.00002868849,0.000006272226,0.00002100593,0.00003826568,0.00003115167],"domain_scores_gemma":[0.9999335,0.00001177257,0.00001420787,0.000006801959,0.00001233043,0.00002149984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004733803,0.0002472241,0.001620933,0.0002729916,0.00003547357,0.001395506,0.0001419909,0.01176227,0.9091938,0.06750586,0.001463965,0.005886565],"study_design_scores_gemma":[0.0009090857,0.004222035,0.02183266,0.0002374303,0.0001958258,0.007844132,0.001031966,0.2318881,0.5639789,0.101793,0.06584926,0.0002176204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559285,0.006965066,0.02045777,0.003760327,0.0003387147,0.0001049356,0.0002333478,0.0002347643,0.01197656],"genre_scores_gemma":[0.9901707,0.002170417,0.005346414,0.0004334863,0.00007821256,0.00003977516,0.0002682867,0.00001716636,0.001475575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684416,"threshold_uncertainty_score":0.005634964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0269833748071311,"score_gpt":0.2903289513522238,"score_spread":0.2633455765450927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}