{"id":"W2600976817","doi":"10.1002/cmdc.201700028","title":"Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2","year":2017,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"AstraZeneca","keywords":"Wnt signaling pathway; Chemistry; Cell biology; Oxidative phosphorylation; Signal transduction; Biochemistry; Phosphorylation; Mechanism of action; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672964,0.0001235436,0.0001710435,0.00001964693,0.0001265706,0.00002191025,0.00009473246,0.0001474504,0.00002476663],"category_scores_gemma":[0.0001884417,0.0001136535,0.00008355402,0.00002423858,0.0001059296,0.00000976412,0.0000822435,0.00005450521,0.000003572836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001866921,"about_ca_system_score_gemma":0.00001858641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004170558,"about_ca_topic_score_gemma":0.000009210195,"domain_scores_codex":[0.9992537,0.00001452609,0.0001856983,0.0002915541,0.0001231381,0.0001313168],"domain_scores_gemma":[0.9992893,0.00001354245,0.0002249881,0.0003306448,0.00007504856,0.00006651939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006688044,0.00004480984,0.0064092,0.00001470644,0.00004700281,5.065415e-7,0.00002189041,0.00002799782,0.9876087,0.0001021508,0.0002647167,0.005391402],"study_design_scores_gemma":[0.0003027536,0.00006013414,0.03620882,0.00002508793,0.00001923612,0.000001194533,0.00001452276,0.0005222516,0.9617204,0.0003955902,0.0006043304,0.0001256601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976204,0.0001285921,0.0003128688,0.0001460153,0.00002515976,0.00008509598,0.00002980046,0.000005549348,0.001646507],"genre_scores_gemma":[0.9985178,0.00004289745,0.0007088082,0.00003143396,0.0001358558,0.00000772053,0.0002593845,0.00001182145,0.0002843011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02979962,"threshold_uncertainty_score":0.4634657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231798747857908,"score_gpt":0.2417187004665211,"score_spread":0.229400712987942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}