{"id":"W2601005007","doi":"10.3233/jad-160133","title":"Apolipoprotein E Isoforms Differentially Regulate Alzheimer’s Disease and Amyloid-β-Induced Inflammatory Response <i>in vivo</i> and <i>in vitro</i>","year":2017,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Ottawa","funders":"National Research Council Canada; Canadian Institutes of Health Research; University of Ottawa","keywords":"Neuroinflammation; Neuroprotection; Calcitriol receptor; Astrocyte; Microglia; Inflammation; In vivo; Apolipoprotein E; Cytokine; Biology; Genetically modified mouse; Tumor necrosis factor alpha; Recombinant DNA; Gene isoform; Receptor; Proinflammatory cytokine; Immunology; Cell biology; Transgene; Pharmacology; Endocrinology; Internal medicine; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002040671,0.0002961197,0.0002009235,0.0002404954,0.0001255661,0.0003305338,0.00009087715,0.0002088992,0.0009725472],"category_scores_gemma":[0.0001458178,0.0001379074,0.0002790034,0.0001756538,0.0001863746,0.0001928436,0.0001107627,0.0003164273,0.0004212594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442995,"about_ca_system_score_gemma":0.0001098609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003315715,"about_ca_topic_score_gemma":0.000477036,"domain_scores_codex":[0.9998512,0.00002645332,0.00002134709,0.00002734812,0.00002968474,0.00004393389],"domain_scores_gemma":[0.99988,0.00001656149,0.0000358525,0.00001078485,0.00002792395,0.0000288894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005822119,0.00004675782,0.0006230655,0.000042012,0.000007674493,0.0001012012,0.00002334926,0.0000135742,0.9977601,0.00003024494,0.00005642867,0.0007133967],"study_design_scores_gemma":[0.00009751735,0.001007399,0.05210937,0.00002144817,0.00007785475,0.001022398,0.0002412781,0.0005417871,0.9406908,0.0001922322,0.003982884,0.00001502596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943184,0.00228285,0.001466152,0.00009016252,0.00004905769,0.0000289648,0.00037817,0.00002773383,0.001358536],"genre_scores_gemma":[0.9898143,0.002897479,0.001713114,0.0001829146,0.00004592956,0.00008948435,0.001170577,0.00002234915,0.004063879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009725472,"threshold_uncertainty_score":0.00325346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797713195843506,"score_gpt":0.3050914740213906,"score_spread":0.2771143420629555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}