{"id":"W2601226883","doi":"10.1016/j.cell.2017.03.012","title":"Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Office of Experimental Program to Stimulate Competitive Research; Montana State University; National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; NIH Office of the Director; University of California, San Francisco; M.J. Murdock Charitable Trust; National Institutes of Health; Canadian Institutes of Health Research; Sandler Foundation; University of California; Amgen","keywords":"Trans-activating crRNA; Biology; CRISPR; Nuclease; RNA; Immune system; Computational biology; Genetics; Cas9; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008615854,0.0001449795,0.0001850998,0.00002053321,0.0000787214,0.00003137072,0.0004151756,0.0001190333,0.00009016369],"category_scores_gemma":[0.00003979113,0.0001375775,0.00008825368,0.00001217033,0.00006283192,0.000002987409,0.0001896595,0.00006900736,0.000003493348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005096165,"about_ca_system_score_gemma":0.00001439672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002846439,"about_ca_topic_score_gemma":0.00003308887,"domain_scores_codex":[0.9992727,0.00002449744,0.0001601151,0.0002461957,0.00009767861,0.0001988073],"domain_scores_gemma":[0.9990748,0.000005893709,0.000123812,0.0006974568,0.0000385819,0.0000595112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001647402,0.0000107892,0.000901544,0.0000433101,0.00001593261,0.000001678195,0.0000465269,0.0001041968,0.9944067,0.00003013324,0.004219797,0.0002029029],"study_design_scores_gemma":[0.000394561,0.00007834384,0.0184374,0.00001007103,0.000007914784,0.000005319291,0.00004065691,0.0001286872,0.9781321,0.0004437616,0.002163027,0.0001581256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738005,0.0002029792,0.02280428,0.00007018493,0.0003107511,0.0001312542,0.00008940238,0.00001021868,0.002580425],"genre_scores_gemma":[0.9965256,0.00004668782,0.002363093,0.00005772151,0.00009561821,0.00000304868,0.00007104591,0.00002204957,0.0008151417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02272509,"threshold_uncertainty_score":0.5610246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897468727163627,"score_gpt":0.3058475079350208,"score_spread":0.2868728206633845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}