{"id":"W2601226883","doi":"10.1016/j.cell.2017.03.012","title":"Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":231,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Office of Experimental Program to Stimulate Competitive Research; Montana State University; National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; NIH Office of the Director; University of California, San Francisco; M.J. Murdock Charitable Trust; National Institutes of Health; Canadian Institutes of Health Research; Sandler Foundation; University of California; Amgen","keywords":"Trans-activating crRNA; Biology; CRISPR; Nuclease; RNA; Immune system; Computational biology; Genetics; Cas9; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001729272,0.0003411288,0.0003350996,0.0003148619,0.0005527971,0.001183,0.0006347958,0.000771323,0.001377447],"category_scores_gemma":[0.0003214056,0.0002564007,0.0003202797,0.0001395731,0.000590669,0.0005772139,0.0003226804,0.001656014,0.0009711865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001261016,"about_ca_system_score_gemma":0.0004892554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029418,"about_ca_topic_score_gemma":0.001143618,"domain_scores_codex":[0.9998685,0.0000136711,0.000009340114,0.00003547206,0.0000434532,0.00002955058],"domain_scores_gemma":[0.9997088,0.00004661935,0.00008965459,0.00004284932,0.00003148706,0.00008056976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000893406,0.0000394089,0.0003932978,0.00002242791,0.000008255924,0.0001954546,0.00004409565,0.0006954825,0.9905953,0.006063489,0.0002605672,0.001592673],"study_design_scores_gemma":[0.00003958357,0.0001617909,0.003469632,0.00001045864,0.00002449909,0.0007874352,0.0001106609,0.02186504,0.9628562,0.003682641,0.006963826,0.00002830173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717072,0.001100548,0.01986621,0.0007255217,0.0001344119,0.00002942917,0.0002039437,0.0005256449,0.005707206],"genre_scores_gemma":[0.9936179,0.000151571,0.003821821,0.0001167237,0.0000155265,0.00001116973,0.0002518605,0.00004571999,0.001967828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377447,"threshold_uncertainty_score":0.009149313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897468727163627,"score_gpt":0.3058475079350208,"score_spread":0.2868728206633845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}