{"id":"W2601245179","doi":"10.1021/acs.biochem.7b00079","title":"Simultaneous Measurement of Glucose-6-phosphate 3-Dehydrogenase (NtdC) Catalysis and the Nonenzymatic Reaction of Its Product: Kinetics and Isotope Effects on the First Step in Kanosamine Biosynthesis","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Reaction rate constant; Kinetic isotope effect; Catalysis; Deprotonation; Reaction rate; Dehydrogenase; Enzyme catalysis; Chemical kinetics; Kinetics; Photochemistry; Stereochemistry; Deuterium; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003763662,0.0005362284,0.0003696702,0.0002497125,0.0001821581,0.0003760008,0.0003982049,0.0005314068,0.0005026598],"category_scores_gemma":[0.0004966214,0.0002663476,0.000316325,0.0003929081,0.0003828273,0.000383612,0.0003090297,0.0009943263,0.0002674163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004237361,"about_ca_system_score_gemma":0.0002726278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095433,"about_ca_topic_score_gemma":0.001128957,"domain_scores_codex":[0.9996855,0.0000413042,0.00001455785,0.0000993881,0.0001050595,0.00005417734],"domain_scores_gemma":[0.9996454,0.0001104945,0.00005245607,0.00003957432,0.00007848931,0.00007354911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009170734,0.00001141396,0.000301766,0.00002061243,0.000004407203,0.00001501383,0.00001664683,0.00005686375,0.9984994,0.00003505847,0.000008858288,0.0009384368],"study_design_scores_gemma":[0.000002580024,0.00004016829,0.001710305,0.000001718555,0.000004947623,0.00003340234,0.000007240405,0.001130703,0.9968466,0.00001948092,0.0001968966,0.000005925524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701785,0.001710404,0.02590209,0.00007654831,0.00005913406,0.00004052892,0.000536656,0.0001942118,0.001302027],"genre_scores_gemma":[0.9805917,0.0009359494,0.01600925,0.00004270231,0.0000143379,0.00005880366,0.0005260138,0.00006077562,0.001760417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095433,"threshold_uncertainty_score":0.003074408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081043679979349,"score_gpt":0.2317888329100572,"score_spread":0.2209783961102637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}