{"id":"W2601259221","doi":"10.1111/hae.13210","title":"Exploring some intersections between pharmacokinetics, factor <scp>VIII</scp> measurement and human morphometrics – impact of recent advances in haemophilia study design on our understanding of optimal haemophilia treatment","year":2017,"lang":"en","type":"letter","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; McMaster University; Impact","funders":"","keywords":"Haemophilia; Bioequivalence; Medicine; Dosing; Haemophilia A; Population; Pharmacokinetics; Blood sampling; Pharmacology; Pediatrics; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1514762,0.001107599,0.002349766,0.001308392,0.000757442,0.004995513,0.002684439,0.002390509,0.005372779],"category_scores_gemma":[0.1479497,0.0006632386,0.001396788,0.002516415,0.007314451,0.008034407,0.003414972,0.005634819,0.0004663161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001418524,"about_ca_system_score_gemma":0.003035868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001330523,"about_ca_topic_score_gemma":0.001756767,"domain_scores_codex":[0.9560888,0.03783506,0.001306307,0.001954071,0.002531797,0.0002840802],"domain_scores_gemma":[0.6973932,0.2743268,0.011448,0.00896819,0.006258919,0.001604918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005110763,0.0007418717,0.07007378,0.007617956,0.004020607,0.0004531291,0.002739242,0.02828488,0.004259099,0.188769,0.02592993,0.6619998],"study_design_scores_gemma":[0.0005049689,0.009092175,0.07178763,0.00289532,0.001704746,0.001116658,0.003003533,0.08401898,0.003310364,0.691178,0.1309669,0.0004206108],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.0984548,0.2834876,0.4149213,0.1871939,0.004516044,0.0004879083,0.0007724953,0.0003440117,0.009821814],"genre_scores_gemma":[0.5470616,0.109166,0.286088,0.03763317,0.01473234,0.001077562,0.0008718377,0.000678098,0.002691387],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1514762,"threshold_uncertainty_score":0.8010925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4832294520093329,"score_gpt":0.4212931146414715,"score_spread":0.06193633736786136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}