{"id":"W2601381407","doi":"10.1200/jco.2013.31.15_suppl.tps2621","title":"A phase I dose-escalation study of TKM-080301, a RNAi therapeutic directed against polo-like kinase 1 (PLK1), in patients with advanced solid tumors: Expansion cohort evaluation of biopsy samples for evidence of pharmacodynamic effects of PLK1 inhibition.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Medicine; Polo-like kinase; Pharmacodynamics; PLK1; Pharmacokinetics; Cohort; Biopsy; Kinase; Pharmacology; Oncology; Internal medicine; Cell cycle; Cancer research; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002289527,0.00201109,0.002055224,0.0006092591,0.000529258,0.00097978,0.001237702,0.00125409,0.00306316],"category_scores_gemma":[0.001275628,0.0007016085,0.001532942,0.0005497233,0.00111747,0.00102183,0.0005358342,0.004416524,0.001036321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00163551,"about_ca_system_score_gemma":0.002182039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212489,"about_ca_topic_score_gemma":0.002963878,"domain_scores_codex":[0.9992986,0.0003088848,0.00003008925,0.0001394169,0.0000739721,0.0001490331],"domain_scores_gemma":[0.9987038,0.0001840852,0.0002235967,0.0001689762,0.00009982523,0.0006197028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5438033,0.2223705,0.01588739,0.0005449337,0.001333602,0.0004397488,0.0007386712,0.004771911,0.1000565,0.0003836183,0.005373565,0.1042963],"study_design_scores_gemma":[0.3167423,0.6515551,0.01959184,0.00001788596,0.0003427459,0.0003938182,0.0001023346,0.001876798,0.006768177,0.0002297322,0.002336429,0.00004290107],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933268,0.000497644,0.0007215132,0.0002827196,0.0000661519,0.003051202,0.0009666578,0.0001032577,0.0009840674],"genre_scores_gemma":[0.9867297,0.0005787337,0.003054192,0.0007204263,0.00009192999,0.004189501,0.002558425,0.00004481844,0.002032197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00306316,"threshold_uncertainty_score":0.01210839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05274939939260948,"score_gpt":0.4298960845736244,"score_spread":0.377146685181015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}