{"id":"W2601381407","doi":"10.1200/jco.2013.31.15_suppl.tps2621","title":"A phase I dose-escalation study of TKM-080301, a RNAi therapeutic directed against polo-like kinase 1 (PLK1), in patients with advanced solid tumors: Expansion cohort evaluation of biopsy samples for evidence of pharmacodynamic effects of PLK1 inhibition.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Medicine; Polo-like kinase; Pharmacodynamics; PLK1; Pharmacokinetics; Cohort; Biopsy; Kinase; Pharmacology; Oncology; Internal medicine; Cell cycle; Cancer research; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001663097,0.0001474366,0.0009345274,0.0001445194,0.00001819499,0.000003206426,0.0001366074,0.0001739883,0.000007342353],"category_scores_gemma":[0.002658725,0.0001170358,0.0001793494,0.0001659163,0.000138782,0.00002664638,0.00004818007,0.0001504861,1.372128e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007084574,"about_ca_system_score_gemma":0.0007375857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006458956,"about_ca_topic_score_gemma":0.000091225,"domain_scores_codex":[0.9966693,0.0005210777,0.002054347,0.0002236509,0.0003835175,0.0001481249],"domain_scores_gemma":[0.9935111,0.001295391,0.003000806,0.0002049778,0.001902368,0.00008539252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01200206,0.01204216,0.1606637,0.0002159819,0.0003864045,0.000003037869,0.0001884994,0.003165133,0.7224082,0.000002841804,0.00003351634,0.08888843],"study_design_scores_gemma":[0.04063005,0.06430425,0.8086843,0.0007422533,0.0006754348,0.000002763081,0.0001740882,0.003378205,0.081097,0.0001247345,0.00001581227,0.0001711268],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967074,0.0007483351,0.000506782,0.00003887118,0.0002531525,0.001706564,0.00003181832,0.000001644565,0.00000539443],"genre_scores_gemma":[0.9981971,0.000586052,0.0009560692,0.00006735399,0.00007118312,0.00006533698,0.0000401337,0.0000159665,8.512613e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6480206,"threshold_uncertainty_score":0.477258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05274939939260948,"score_gpt":0.4298960845736244,"score_spread":0.377146685181015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}