{"id":"W2601522016","doi":"10.2337/db16-1329","title":"A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Münchner Zentrum für Gesundheitswissenschaften; Biomedical Research Council; NIH Office of the Director; National Medical Research Council; MRC-PHE Centre for Environment and Health; Novo Nordisk Fonden; National Institute of General Medical Sciences; Centers for Disease Control and Prevention; Diabetesliitto; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; Augustinus Fonden; National Human Genome Research Institute; University of Texas Health Science Center at Houston; Danmarks Frie Forskningsfond; Medical Research Council; Tartu Ülikool; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; Juho Vainion Säätiö; Novo Nordisk; Hjärt-Lungfonden; Suomen Kulttuurirahasto; National Institute on Aging; Helsefonden; British Heart Foundation; Bundesministerium für Bildung und Forschung; Helmholtz Zentrum München; Kela; Samfundet Folkhälsan; Päivikki ja Sakari Sohlbergin Säätiö; National Institute of Mental Health; Eesti Teadusagentuur; Steno Diabetes Center Copenhagen; National Institute for Health Research Health Protection Research Unit; European Commission; National Research Foundation; Folkhälsanin Tutkimussäätiö; National Institute for Health and Care Research; Sundhed og Sygdom, Det Frie Forskningsråd; Johns Hopkins University; Imperial College London; National Institutes of Health; Sihtasutus Archimedes; National University of Singapore; National Cancer Institute; Lundbeckfonden; Foundation for Cardiovascular Research; Finska Läkaresällskapet; Atlantic Canada Opportunities Agency; National Institute of Diabetes and Digestive and Kidney Diseases; Helsingin ja Uudenmaan Sairaanhoitopiiri; Lunds Universitet; King's College London; Jalmari ja Rauha Ahokkaan Säätiö; Diabetestutkimussäätiö; Korea Centers for Disease Control and Prevention; Imperial College Healthcare NHS Trust; Wellcome Trust; Swiss Institute of Bioinformatics; Hjerteforeningen; Tekes; Wellcome; American Diabetes Association","keywords":"Type 2 diabetes; Medicine; Internal medicine; Diabetes mellitus; Endocrinology; Insulin; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002404816,0.0003618218,0.000230952,0.0007315564,0.0005020921,0.0004030658,0.0002369443,0.0003665705,0.00168279],"category_scores_gemma":[0.0006869363,0.0001523914,0.000316765,0.0006478016,0.0002799562,0.00008942494,0.0002530036,0.0002766494,0.0001825665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344607,"about_ca_system_score_gemma":0.0001429738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004493795,"about_ca_topic_score_gemma":0.004195035,"domain_scores_codex":[0.9997866,0.00003810209,0.00002513476,0.00008035823,0.00003774671,0.00003201793],"domain_scores_gemma":[0.999772,0.00006458996,0.00008502271,0.00002422251,0.00001755256,0.00003673419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001985099,0.00009416143,0.8435726,0.00006291945,0.0004643816,0.003520503,0.0004324589,0.0004927551,0.1366015,0.0002908632,0.0004041254,0.01207871],"study_design_scores_gemma":[0.00002926822,0.000132278,0.9925951,0.00001354838,0.0001645477,0.003309696,0.00009615185,0.000457396,0.002517601,0.0001559547,0.0005158935,0.00001245744],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990051,0.0001443682,0.0003327398,0.00002309885,0.000006111604,0.000004273253,0.0001713814,0.000008693717,0.0003043324],"genre_scores_gemma":[0.9994253,0.00005239918,0.0002061094,0.00001685256,0.000007869173,0.000002875857,0.0001676299,0.000003289591,0.000117727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004493795,"threshold_uncertainty_score":0.008935273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765522108787812,"score_gpt":0.240386175500362,"score_spread":0.2227309544124839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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