{"id":"W2601522016","doi":"10.2337/db16-1329","title":"A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk","year":2017,"lang":"en","type":"article","venue":"Diabetes","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Münchner Zentrum für Gesundheitswissenschaften; Biomedical Research Council; NIH Office of the Director; National Medical Research Council; MRC-PHE Centre for Environment and Health; Novo Nordisk Fonden; National Institute of General Medical Sciences; Centers for Disease Control and Prevention; Diabetesliitto; Sydäntutkimussäätiö; Emil Aaltosen Säätiö; Augustinus Fonden; National Human Genome Research Institute; University of Texas Health Science Center at Houston; Danmarks Frie Forskningsfond; Medical Research Council; Tartu Ülikool; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; Juho Vainion Säätiö; Novo Nordisk; Hjärt-Lungfonden; Suomen Kulttuurirahasto; National Institute on Aging; Helsefonden; British Heart Foundation; Bundesministerium für Bildung und Forschung; Helmholtz Zentrum München; Kela; Samfundet Folkhälsan; Päivikki ja Sakari Sohlbergin Säätiö; National Institute of Mental Health; Eesti Teadusagentuur; Steno Diabetes Center Copenhagen; National Institute for Health Research Health Protection Research Unit; European Commission; National Research Foundation; Folkhälsanin Tutkimussäätiö; National Institute for Health and Care Research; Sundhed og Sygdom, Det Frie Forskningsråd; Johns Hopkins University; Imperial College London; National Institutes of Health; Sihtasutus Archimedes; National University of Singapore; National Cancer Institute; Lundbeckfonden; Foundation for Cardiovascular Research; Finska Läkaresällskapet; Atlantic Canada Opportunities Agency; National Institute of Diabetes and Digestive and Kidney Diseases; Helsingin ja Uudenmaan Sairaanhoitopiiri; Lunds Universitet; King's College London; Jalmari ja Rauha Ahokkaan Säätiö; Diabetestutkimussäätiö; Korea Centers for Disease Control and Prevention; Imperial College Healthcare NHS Trust; Wellcome Trust; Swiss Institute of Bioinformatics; Hjerteforeningen; Tekes; Wellcome; American Diabetes Association","keywords":"Type 2 diabetes; Medicine; Internal medicine; Diabetes mellitus; Endocrinology; Insulin; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008163195,0.0001727844,0.000363494,0.0000860185,0.0004208396,0.000136334,0.0001065235,0.0001178172,0.00002174133],"category_scores_gemma":[0.003030817,0.0001104634,0.00008047473,0.0002238121,0.00007183043,0.0002014581,0.00004142056,0.0003455975,0.000003992545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006363316,"about_ca_system_score_gemma":0.00003884253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003760084,"about_ca_topic_score_gemma":0.0000559683,"domain_scores_codex":[0.9987693,0.0001524761,0.0002278877,0.0002714957,0.0002908259,0.0002880069],"domain_scores_gemma":[0.9988184,0.0003017832,0.0002779258,0.0004265031,0.0001161571,0.00005923698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001099576,0.00005794547,0.9856721,0.00003151526,0.0001855377,0.000009742592,0.0007246171,0.000003914321,0.00357414,0.00001704099,0.00003917747,0.009673312],"study_design_scores_gemma":[0.001393796,0.0001244799,0.9954133,0.0002618358,0.0001632841,0.000002247996,0.0001934615,0.000679161,0.001364657,0.0002096765,0.00003999956,0.000154096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984623,0.0002789685,0.00001203876,0.0003399466,0.0001268701,0.0003034572,0.00001874685,0.00004387496,0.0004138554],"genre_scores_gemma":[0.99921,0.00003927127,0.0001328884,0.0004025406,0.0000996079,0.00001693753,0.00004665058,0.00002375348,0.00002837497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009741243,"threshold_uncertainty_score":0.4504565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765522108787812,"score_gpt":0.240386175500362,"score_spread":0.2227309544124839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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