{"id":"W2601555696","doi":"10.1200/jco.2013.31.15_suppl.8535","title":"A phase II study of single agent mocetinostat, an oral isotype-selective histone deacetylase (HDAC) inhibitor, in patients with diffuse large cell B-cell (DLBCL) and follicular (FL) lymphomas.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Charles-Le Moyne; Ottawa Hospital; Jewish General Hospital; Pyrogenesis (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacodynamics; Internal medicine; Pharmacokinetics; Diffuse large B-cell lymphoma; Gastroenterology; Lymphoma; Follicular lymphoma; Phases of clinical research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001450114,0.001131136,0.001945868,0.0003992291,0.0003494208,0.0009513896,0.0007639341,0.00102002,0.003249588],"category_scores_gemma":[0.0008775013,0.0007036354,0.0009179276,0.0004077177,0.000991906,0.00096373,0.0003495782,0.002595291,0.0007859048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008065208,"about_ca_system_score_gemma":0.001476721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008273846,"about_ca_topic_score_gemma":0.001986205,"domain_scores_codex":[0.9995996,0.0001688903,0.00002275323,0.00007864119,0.00003516797,0.0000949164],"domain_scores_gemma":[0.9991469,0.0001384841,0.0001261971,0.00005261374,0.00004487661,0.0004908444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7189383,0.1202514,0.01526039,0.000903233,0.001223167,0.0006338765,0.0006041513,0.002674858,0.04709278,0.0003442684,0.0031719,0.08890165],"study_design_scores_gemma":[0.5813953,0.4007622,0.01188397,0.00002426766,0.0002875025,0.0003749188,0.00009224226,0.001106602,0.002042131,0.000148345,0.001859947,0.0000226177],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943565,0.001487925,0.0004379722,0.0002817237,0.00008250094,0.001855976,0.0004915505,0.00004518777,0.0009606629],"genre_scores_gemma":[0.9920267,0.001405516,0.001208464,0.0007114731,0.0001432571,0.001807337,0.001350251,0.00001597101,0.001331021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003249588,"threshold_uncertainty_score":0.01087093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03044870683418619,"score_gpt":0.3755182046731341,"score_spread":0.3450694978389479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}