{"id":"W2601563152","doi":"10.3389/fnagi.2017.00089","title":"Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson’s Disease-Associated LRRK2 Gene Mutations","year":2017,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"LRRK2; Oxidative stress; CTL*; Parkinson's disease; Internal medicine; Cerebrospinal fluid; Medicine; Endocrinology; Montreal Cognitive Assessment; Disease; Immunology; Cognitive impairment; Immune system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002112176,0.0002786218,0.0004001644,0.000311495,0.0005053481,0.0001525102,0.0003871522,0.0000561838,0.000009189355],"category_scores_gemma":[0.0005022298,0.0002543515,0.00006256119,0.0003814954,0.0003347988,0.0003947268,0.00008952111,0.0002413912,0.000003157502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004437775,"about_ca_system_score_gemma":0.000511352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002243794,"about_ca_topic_score_gemma":0.0005019842,"domain_scores_codex":[0.9975487,0.0001576444,0.0002718807,0.0008728165,0.0005463627,0.0006025944],"domain_scores_gemma":[0.998485,0.00004595002,0.0002639298,0.0006430371,0.0000557686,0.0005063481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009604212,0.0005896812,0.9944229,0.00002043043,0.00001906757,0.00130053,0.0001726098,0.00007925853,0.001419529,0.000005728805,0.0001372105,0.0008726278],"study_design_scores_gemma":[0.00426016,0.0002770268,0.9835131,0.0003718723,0.00007681753,0.000004905136,0.0001626081,0.009388844,0.001340485,0.0002004438,0.0001737583,0.0002299437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960036,0.0002730098,0.001318089,0.000586456,0.0006514182,0.0006239193,0.0003549861,0.00005902509,0.0001294811],"genre_scores_gemma":[0.9958457,0.0001157286,0.00303785,0.0006522353,0.00002980089,0.00009816104,0.0001123726,0.00003124943,0.00007691286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01090977,"threshold_uncertainty_score":0.9999909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181747199093017,"score_gpt":0.2706380362079872,"score_spread":0.2524633162986855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}