{"id":"W2601571152","doi":"10.1016/s1474-4422(17)30056-x","title":"Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies","year":2017,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"TRIUMF; Centre for Movement Disorders; University of British Columbia","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; TRIUMF; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Dopamine transporter; Dopaminergic; LRRK2; Parkinson's disease; Dopamine; Parkinsonism; Vesicular monoamine transporter; Serotonin transporter; Psychology; Medicine; Neurochemical; Internal medicine; Disease; Neuroscience; Monoamine neurotransmitter; Endocrinology; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000841557,0.0004159902,0.0004388397,0.0004194069,0.0003802962,0.0006083582,0.0002678733,0.0006831094,0.001293061],"category_scores_gemma":[0.001470316,0.0005660316,0.00047556,0.0005105968,0.0003791022,0.0007326461,0.0002981511,0.0005313739,0.000252878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003498331,"about_ca_system_score_gemma":0.0001305384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003803309,"about_ca_topic_score_gemma":0.008079031,"domain_scores_codex":[0.9997259,0.00007147212,0.00003311208,0.0001110065,0.0000308245,0.00002759577],"domain_scores_gemma":[0.999175,0.0001487747,0.0003599056,0.00008964269,0.0001356253,0.00009088329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008592026,0.0001238409,0.9921354,0.00004083711,0.0007520876,0.0003088749,0.0001481037,0.0000422533,0.002844103,0.00002689936,0.0001060703,0.002612342],"study_design_scores_gemma":[0.000009081757,0.0001523914,0.9990169,0.000002777268,0.0001223841,0.0003793929,0.00005062668,0.00003716056,0.0001059505,0.00001312762,0.0001072562,0.000002819155],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983714,0.000821787,0.0001589667,0.00002799535,0.000007058636,0.00001067563,0.0002350729,0.000005318386,0.0003616959],"genre_scores_gemma":[0.9987111,0.000295037,0.0001614497,0.00005704115,0.00001061346,0.00001103477,0.0003851995,0.000006155482,0.0003623093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003803309,"threshold_uncertainty_score":0.007562339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1002204202382851,"score_gpt":0.3879061225832022,"score_spread":0.2876857023449171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}