{"id":"W2601651086","doi":"10.1182/blood.v128.22.1173.1173","title":"Development of an Optimized rAAV2/6 Human Factor 8 cDNA Vector Cassette for Hemophilia a Gene Therapy","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Factor IX; Medicine; Vector (molecular biology); Clotting factor; Transgene; Immunology; Recombinant DNA; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004447323,0.0006160098,0.0005161862,0.0006025448,0.0002774984,0.0005592803,0.0005733587,0.0008297572,0.003103021],"category_scores_gemma":[0.0002465446,0.000363488,0.0004772334,0.000312059,0.0002798076,0.0003642295,0.0003322557,0.001371742,0.002649068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005129596,"about_ca_system_score_gemma":0.0004747839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008390736,"about_ca_topic_score_gemma":0.0008797005,"domain_scores_codex":[0.99953,0.00006860678,0.00005817492,0.0001073899,0.0001600408,0.00007583643],"domain_scores_gemma":[0.9998302,0.00002605443,0.00004932827,0.00001667026,0.00003576715,0.00004194644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005038053,0.00008125188,0.00006438467,0.00007441132,0.000007714399,0.00007030665,0.00003194238,0.0002546601,0.9930537,0.0007726706,0.0003194209,0.005219032],"study_design_scores_gemma":[0.00006358619,0.0006935928,0.0008530657,0.00004369052,0.00005398559,0.0005499031,0.00002597673,0.003389742,0.9524396,0.0001415838,0.04171766,0.00002771722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6681637,0.004316326,0.2919756,0.0007880714,0.0007007745,0.003905026,0.005795144,0.002527996,0.0218274],"genre_scores_gemma":[0.6528465,0.003379405,0.2832007,0.0003578758,0.00006670508,0.002199175,0.01055141,0.0005922838,0.04680593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003103021,"threshold_uncertainty_score":0.01038063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03572721995617079,"score_gpt":0.317467374362537,"score_spread":0.2817401544063662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}