{"id":"W2601669236","doi":"10.1007/s00432-017-2394-6","title":"Demethylating agent decitabine disrupts tumor-induced immune tolerance by depleting myeloid-derived suppressor cells","year":2017,"lang":"en","type":"article","venue":"Journal of Cancer Research and Clinical Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Natural Science Foundation of China","keywords":"Immune system; In vivo; Cancer research; Myeloid-derived Suppressor Cell; Immunology; Immune tolerance; Adoptive cell transfer; Immunotherapy; Decitabine; Myeloid; T cell; Medicine; Biology; Suppressor; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.007185447,0.0002596447,0.001247609,0.0001408754,0.001113379,0.0001155173,0.001267841,0.0005316574,0.0007579714],"category_scores_gemma":[0.003355816,0.0002090844,0.0002985222,0.0001028559,0.001596753,0.0002891963,0.0006795951,0.003172416,0.00006421642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003181237,"about_ca_system_score_gemma":0.0009157623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006686815,"about_ca_topic_score_gemma":0.0002067718,"domain_scores_codex":[0.9948102,0.001507094,0.001926482,0.0004768787,0.000267457,0.001011893],"domain_scores_gemma":[0.9927602,0.003568068,0.001927048,0.0006293667,0.0009192959,0.0001959876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002247779,0.000400889,0.009280151,0.00003776267,0.000470327,0.0001304506,0.000186883,0.000003843514,0.8749129,0.00001852592,0.007765861,0.1045446],"study_design_scores_gemma":[0.0110232,0.005866034,0.05974688,0.0004061104,0.0001398475,0.000161823,0.0005879679,0.00001953094,0.7271947,0.0003581507,0.1941022,0.0003935627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631599,0.02675672,0.00004128651,0.004364265,0.004226111,0.0003055221,0.00001938377,0.00001040842,0.001116416],"genre_scores_gemma":[0.9867157,0.01071004,0.0003748766,0.0003247409,0.000584528,0.00003047484,0.000003633507,0.00003650844,0.001219502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1863364,"threshold_uncertainty_score":0.9991273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1149338688343727,"score_gpt":0.475327798880573,"score_spread":0.3603939300462002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}