{"id":"W2601776127","doi":"10.1002/jbmr.3143","title":"BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial","year":2017,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Novartis Institutes for BioMedical Research; Mereo BioPharma","keywords":"Medicine; Sclerostin; N-terminal telopeptide; Bone mineral; Bone remodeling; Tolerability; Osteogenesis imperfecta; Internal medicine; Procollagen peptidase; Bone density; Gastroenterology; Adverse effect; Osteocalcin; Endocrinology; Osteoporosis; Alkaline phosphatase; Chemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001475601,0.001079331,0.001808916,0.0003059154,0.000312373,0.0005178388,0.000457474,0.0009759802,0.002547729],"category_scores_gemma":[0.0008797889,0.0004362387,0.0008411137,0.0002652397,0.0006059633,0.0005167087,0.0002603393,0.001313288,0.0004627461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004043543,"about_ca_system_score_gemma":0.0007916918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005134742,"about_ca_topic_score_gemma":0.001215777,"domain_scores_codex":[0.9995435,0.0002371581,0.00003530746,0.00006500097,0.00006224532,0.0000568355],"domain_scores_gemma":[0.9994054,0.0001177288,0.000141649,0.00003556037,0.00004879071,0.0002508513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9026251,0.02145252,0.00261799,0.0007067836,0.001040117,0.0001362067,0.0001020396,0.0005714525,0.01859139,0.0001351383,0.001271903,0.05074944],"study_design_scores_gemma":[0.7910166,0.1982439,0.00807838,0.00002396017,0.0003110674,0.0001040302,0.00002083662,0.0004426758,0.000816363,0.00009043759,0.0008372401,0.00001458263],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956213,0.001776216,0.000213462,0.0002182594,0.00008204859,0.0008074874,0.0003445251,0.00005504727,0.0008817215],"genre_scores_gemma":[0.992259,0.001690267,0.001142067,0.0006918424,0.0002887567,0.001773597,0.0008711337,0.00001261612,0.001270704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002547729,"threshold_uncertainty_score":0.008523047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263582879236614,"score_gpt":0.4031673583927045,"score_spread":0.3605315296003383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}