{"id":"W2601776127","doi":"10.1002/jbmr.3143","title":"BPS804 Anti-Sclerostin Antibody in Adults With Moderate Osteogenesis Imperfecta: Results of a Randomized Phase 2a Trial","year":2017,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Novartis Institutes for BioMedical Research; Mereo BioPharma","keywords":"Medicine; Sclerostin; N-terminal telopeptide; Bone mineral; Bone remodeling; Tolerability; Osteogenesis imperfecta; Internal medicine; Procollagen peptidase; Bone density; Gastroenterology; Adverse effect; Osteocalcin; Endocrinology; Osteoporosis; Alkaline phosphatase; Chemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005421651,0.0001509921,0.0007969145,0.0003768344,0.0001723452,0.00009568066,0.000263134,0.0001258811,0.000009707544],"category_scores_gemma":[0.005612211,0.0001071758,0.0001652472,0.0001409412,0.0005438102,0.00002739945,0.0002108376,0.00035764,7.003712e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001688678,"about_ca_system_score_gemma":0.0003672554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007105864,"about_ca_topic_score_gemma":0.0004296755,"domain_scores_codex":[0.9973322,0.0006145258,0.0007213408,0.0002980808,0.0006310882,0.0004027921],"domain_scores_gemma":[0.9976544,0.0002400995,0.0004525165,0.0004002693,0.001097035,0.0001556553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5405304,0.0002964159,0.0004026883,0.00004319124,0.0000858685,0.00008725539,0.0001629365,0.000009705747,0.4548295,0.000007122516,0.0002170755,0.003327771],"study_design_scores_gemma":[0.8782049,0.007253628,0.002572363,0.0003869932,0.00002966927,0.00007280485,0.0002951962,0.0004419112,0.1102269,0.00005854013,0.0002828728,0.000174151],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955466,0.002361504,0.0000522936,0.0006302155,0.00004254757,0.000772369,0.00003114853,9.487036e-7,0.0005623272],"genre_scores_gemma":[0.9956481,0.003506851,0.0001522341,0.000006516641,0.0001978727,0.00001855436,0.00002030212,0.00001886943,0.0004306519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3446026,"threshold_uncertainty_score":0.6718746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263582879236614,"score_gpt":0.4031673583927045,"score_spread":0.3605315296003383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}