{"id":"W2601888676","doi":"10.1101/121822","title":"<i>rahu</i> is a mutant allele of <i>Dnmt3c</i> , encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Memorial Sloan-Kettering Cancer Center; Hospital for Sick Children; Carnegie Institution of Washington","keywords":"Biology; Genetics; DNA methyltransferase; DNMT3B; Retrotransposon; Synapsis; DNA methylation; Mutant; Methyltransferase; Transposable element; Molecular biology; Methylation; DNA; Gene; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001524017,0.0009668621,0.000389264,0.0008699309,0.0004185257,0.0002783686,0.0007570801,0.0009600794,0.004562708],"category_scores_gemma":[0.0001117086,0.0003834016,0.0006260429,0.0002393687,0.0006772488,0.0001856119,0.0006301582,0.001239799,0.001469251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004565369,"about_ca_system_score_gemma":0.0002851814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083472,"about_ca_topic_score_gemma":0.001866865,"domain_scores_codex":[0.9996612,0.00004497702,0.0000376521,0.00009311557,0.0001086916,0.00005436307],"domain_scores_gemma":[0.9997229,0.00003416854,0.0001034362,0.0000283972,0.00001205372,0.00009908271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003642741,0.00001766371,0.0001113006,0.00001481156,0.000009359063,0.0001690808,0.00000864562,0.00003372495,0.9987526,0.000170207,0.00006336528,0.0006127662],"study_design_scores_gemma":[0.00006671722,0.0003120353,0.008154931,0.00001780525,0.00004694022,0.003159549,0.00004103768,0.001109553,0.9778557,0.0001326474,0.009082892,0.00002008377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772069,0.0008899142,0.01087645,0.0004044216,0.0001155413,0.0002136988,0.003338918,0.00162847,0.005325533],"genre_scores_gemma":[0.966094,0.000496286,0.01402533,0.0002631696,0.00003249603,0.0001684721,0.00277762,0.0005054384,0.01563723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004562708,"threshold_uncertainty_score":0.0152638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029266196902742,"score_gpt":0.2568161218865744,"score_spread":0.2365234599175469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}