{"id":"W2601976570","doi":"10.1161/res.117.suppl_1.23","title":"Abstract 23: Disruption of TRAF2-TAK1-NF-κB Signaling Axis Triggers K-48 Linked Poly-Ubiquitylation of RIP1 and Necrotic Cell Death in Doxorubicin Cardiotoxicity","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Cell biology; Programmed cell death; Myocyte; TRAF2; IκB kinase; NF-κB; IκBα; Biology; Signal transduction; PI3K/AKT/mTOR pathway; Doxorubicin; Phosphorylation; Apoptosis; Cancer research; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057888,0.0003870289,0.0002447109,0.0001152734,0.0001715002,0.000276313,0.0001720383,0.000299286,0.005630174],"category_scores_gemma":[0.00006532065,0.0001182793,0.0002914356,0.00008651763,0.0001846519,0.000217845,0.0001873439,0.0006458058,0.001175185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053903,"about_ca_system_score_gemma":0.0001726901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002475117,"about_ca_topic_score_gemma":0.0003164393,"domain_scores_codex":[0.9998989,0.0000124508,0.00001363953,0.00002518022,0.00002252502,0.00002734322],"domain_scores_gemma":[0.9999365,0.000004947464,0.00002142366,0.000005554785,0.000006302157,0.00002527164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002359897,0.00003119116,0.00008023188,0.00006756673,0.000006699231,0.000129912,0.000008570776,0.0000360679,0.9985488,0.00008156058,0.0001230259,0.00065032],"study_design_scores_gemma":[0.00005129826,0.0003499088,0.005874768,0.00001997064,0.00002060005,0.000822545,0.00003376049,0.0004249913,0.9875787,0.00009317333,0.004724776,0.000005427089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983068,0.004992497,0.004209065,0.0004329139,0.0002458053,0.00006460564,0.001714982,0.0001966896,0.005075479],"genre_scores_gemma":[0.9896349,0.001329988,0.001020662,0.0001351389,0.00002304482,0.00005367769,0.001273132,0.00002326631,0.006506293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005630174,"threshold_uncertainty_score":0.01883477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09563229662178499,"score_gpt":0.3504901376997051,"score_spread":0.2548578410779201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}