{"id":"W2601976570","doi":"10.1161/res.117.suppl_1.23","title":"Abstract 23: Disruption of TRAF2-TAK1-NF-κB Signaling Axis Triggers K-48 Linked Poly-Ubiquitylation of RIP1 and Necrotic Cell Death in Doxorubicin Cardiotoxicity","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Cell biology; Programmed cell death; Myocyte; TRAF2; IκB kinase; NF-κB; IκBα; Biology; Signal transduction; PI3K/AKT/mTOR pathway; Doxorubicin; Phosphorylation; Apoptosis; Cancer research; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002350316,0.0001241606,0.0002351775,0.0002512267,0.00006179435,0.00002480988,0.0001319076,0.0002556147,0.00001688375],"category_scores_gemma":[0.0004917533,0.0001303431,0.00007760905,0.0003129325,0.0001296741,0.00001826742,0.00006368766,0.0002327576,0.000004715583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006256711,"about_ca_system_score_gemma":0.0002158612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004839545,"about_ca_topic_score_gemma":0.00005790551,"domain_scores_codex":[0.9981406,0.0003352486,0.0004311294,0.0003370087,0.0004761076,0.0002798941],"domain_scores_gemma":[0.9989054,0.0000708986,0.0002336905,0.0002749991,0.0003816627,0.0001333817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001682401,0.00008495427,0.07484795,0.0001774431,0.00001635827,0.000001854582,0.0004374788,0.0020728,0.9198242,0.00004014936,0.00001654253,0.002312038],"study_design_scores_gemma":[0.001148404,0.0001880088,0.2047484,0.00006280765,0.00001023381,0.000002644107,0.0002712927,0.003325201,0.789682,0.0003762228,0.00004695563,0.0001378639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960264,0.001126873,0.0009513362,0.00004197843,0.00004133145,0.000587054,0.00002304558,0.000007308769,0.001194654],"genre_scores_gemma":[0.9993526,0.00006706414,0.000256732,0.000007937256,0.00008764234,0.00002480542,0.0001366916,0.00001759909,0.00004887865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1301422,"threshold_uncertainty_score":0.5315236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09563229662178499,"score_gpt":0.3504901376997051,"score_spread":0.2548578410779201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}