{"id":"W2601984321","doi":"10.18632/oncotarget.16464","title":"A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; National Center for Advancing Translational Sciences; Adenoid Cystic Carcinoma Research Foundation","keywords":"Vorinostat; Medicine; Adenoid cystic carcinoma; Internal medicine; Panobinostat; Adverse effect; Progressive disease; Oncology; Histone deacetylase inhibitor; Phases of clinical research; Gastroenterology; Histone deacetylase; Carcinoma; Clinical trial; Disease; Histone; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000349656,0.0001957514,0.0003304531,0.0001075136,0.0001338565,0.00002969378,0.0005296986,0.00006693996,0.00004675428],"category_scores_gemma":[0.0007482495,0.0001722495,0.00006793301,0.00009524394,0.0001430221,0.00001227086,0.0002566323,0.0001843898,0.00001815754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000451354,"about_ca_system_score_gemma":0.0002695203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002409037,"about_ca_topic_score_gemma":0.00145222,"domain_scores_codex":[0.9982827,0.0001703577,0.000397954,0.0004688005,0.0003121847,0.0003680382],"domain_scores_gemma":[0.9985002,0.00003166555,0.0002138038,0.000984839,0.0001360853,0.0001334419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01413875,0.02000772,0.0962206,0.0004754096,0.000274807,0.001756176,0.002567485,0.0002658658,0.8240846,0.00002996659,0.006954841,0.03322375],"study_design_scores_gemma":[0.1046182,0.07815096,0.05983522,0.0004521107,0.0002360421,0.0001692424,0.004692913,0.002057,0.6791112,0.0001108008,0.06835063,0.002215677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978657,0.0005572165,0.0001093504,0.00004595938,0.0002089718,0.0006899379,0.00008268829,0.000005801595,0.0004343419],"genre_scores_gemma":[0.9979027,0.00005030291,0.0007712563,0.00001526475,0.00008659611,0.00008845059,0.00006347493,0.00003128761,0.0009906815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1449734,"threshold_uncertainty_score":0.7024132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03124608134337072,"score_gpt":0.3728440966919328,"score_spread":0.3415980153485621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}