{"id":"W2601984321","doi":"10.18632/oncotarget.16464","title":"A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health; National Center for Advancing Translational Sciences; Adenoid Cystic Carcinoma Research Foundation","keywords":"Vorinostat; Medicine; Adenoid cystic carcinoma; Internal medicine; Panobinostat; Adverse effect; Progressive disease; Oncology; Histone deacetylase inhibitor; Phases of clinical research; Gastroenterology; Histone deacetylase; Carcinoma; Clinical trial; Disease; Histone; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066337,0.0008489633,0.001710879,0.0003592801,0.0004035042,0.0008765866,0.0005311934,0.0008591191,0.003618473],"category_scores_gemma":[0.0007270194,0.0003754484,0.001094587,0.0003075864,0.0006213037,0.0006085638,0.0003183475,0.002074411,0.0007221163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006826174,"about_ca_system_score_gemma":0.001535569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571859,"about_ca_topic_score_gemma":0.004129595,"domain_scores_codex":[0.9997463,0.0001135902,0.00001211285,0.00004150158,0.00003473197,0.00005185066],"domain_scores_gemma":[0.9996775,0.00006207374,0.0000357245,0.00003055582,0.00002406526,0.0001700289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4664385,0.1267324,0.008696675,0.00162622,0.001565637,0.001566487,0.0006088475,0.003787885,0.1163945,0.0007889133,0.01145048,0.2603433],"study_design_scores_gemma":[0.4782593,0.4929571,0.01227547,0.00007136007,0.0004652095,0.0006840282,0.0001589601,0.001576283,0.005211204,0.000348154,0.00794986,0.00004303512],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985959,0.004650851,0.0004457106,0.000904137,0.0002574232,0.003204726,0.0007767194,0.00006265277,0.003738755],"genre_scores_gemma":[0.9768545,0.007625691,0.001731678,0.001677006,0.0002584648,0.003689237,0.00234357,0.0000469884,0.005772754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003618473,"threshold_uncertainty_score":0.01210499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03124608134337072,"score_gpt":0.3728440966919328,"score_spread":0.3415980153485621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}