{"id":"W2602025587","doi":"10.1371/journal.pone.0174413","title":"Biophysical characterization of the b-HLH-LZ of ΔMax, an alternatively spliced isoform of Max found in tumor cells: Towards the validation of a tumor suppressor role for the Max homodimers","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Enhancer; Biology; Leucine zipper; Alternative splicing; Transcription factor; Gene isoform; Gene; Promoter; Basic helix-loop-helix; DNA; Molecular biology; Suppressor; DNA-binding protein; Genetics; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102966,0.000154084,0.0000905658,0.0001168224,0.00008527548,0.0001910065,0.0001287467,0.0001528001,0.0007052372],"category_scores_gemma":[0.0001381597,0.00006847508,0.0001031117,0.0000899909,0.0001489765,0.0001685306,0.0001018725,0.0003231021,0.0002463855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001115174,"about_ca_system_score_gemma":0.00005053231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001956976,"about_ca_topic_score_gemma":0.0001087694,"domain_scores_codex":[0.9999579,0.00000627659,0.000004388725,0.00001109497,0.00001362316,0.00000671848],"domain_scores_gemma":[0.9999112,0.00001696152,0.00002325214,0.00001017456,0.00001207225,0.0000264079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000308162,0.000005748509,0.0002242376,0.000005796811,0.000001234458,0.0000151044,0.000007849266,0.00001275075,0.9994778,0.00003488924,0.000007358964,0.0001763992],"study_design_scores_gemma":[0.00001013499,0.0001234153,0.01655388,0.000003244144,0.000007614893,0.0003436812,0.00007027392,0.001544557,0.9792271,0.00007735559,0.002031971,0.000006762816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972998,0.0002657731,0.001732881,0.00004560344,0.000007782217,0.000006563216,0.0002332013,0.00001397981,0.0003944171],"genre_scores_gemma":[0.9970816,0.0001772885,0.001203453,0.00003931016,0.000007287554,0.00001025403,0.000603322,0.00001188527,0.0008655481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007052372,"threshold_uncertainty_score":0.002359271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04488320683797191,"score_gpt":0.2565435863176971,"score_spread":0.2116603794797252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}