{"id":"W2602060348","doi":"10.1021/acs.bioconjchem.6b00604","title":"Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation","year":2017,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco","keywords":"Allosteric regulation; Chemistry; Cooperativity; CYP3A4; Cytochrome P450; Allosteric enzyme; Cooperative binding; Bioconjugation; Enzyme; Binding site; Biochemistry; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009035611,0.0007719281,0.0009053283,0.0001034298,0.0009131243,0.0001945169,0.001405103,0.001205426,0.002682484],"category_scores_gemma":[0.0001947032,0.0008454966,0.00034407,0.0001655722,0.001170591,0.0004451014,0.0006224643,0.00102319,0.0002449084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001566009,"about_ca_system_score_gemma":0.0003453623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005243447,"about_ca_topic_score_gemma":0.000001373611,"domain_scores_codex":[0.9961906,0.000260326,0.001202473,0.0009675219,0.0004521213,0.0009269551],"domain_scores_gemma":[0.9953775,0.0001417243,0.002071583,0.001377118,0.0004540562,0.0005780361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006417892,0.0007502133,0.001517485,0.001373343,0.0006198538,0.00002925542,0.000382548,0.00004384462,0.9710096,0.00005643187,0.000761786,0.02281381],"study_design_scores_gemma":[0.00415977,0.0001111775,0.00901923,0.0001815799,0.0006318533,0.00003522947,0.0000615446,0.001620883,0.9266277,0.0003716419,0.05641466,0.0007647632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809095,0.002428736,0.0001743683,0.001711611,0.001344397,0.001321117,0.0004942167,0.00008021136,0.0115358],"genre_scores_gemma":[0.9925026,0.001945617,0.0002387395,0.0005644187,0.001469756,0.0001495081,0.0002497032,0.0001011278,0.002778476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05565287,"threshold_uncertainty_score":0.9993996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09445168265934384,"score_gpt":0.411613211441319,"score_spread":0.3171615287819751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}