{"id":"W2602060348","doi":"10.1021/acs.bioconjchem.6b00604","title":"Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation","year":2017,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco","keywords":"Allosteric regulation; Chemistry; Cooperativity; CYP3A4; Cytochrome P450; Allosteric enzyme; Cooperative binding; Bioconjugation; Enzyme; Binding site; Biochemistry; Active site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818509,0.0003024983,0.0001689964,0.00009906067,0.0001235031,0.0001594737,0.0001975838,0.0002103068,0.0005496238],"category_scores_gemma":[0.0002645073,0.0001160079,0.0002256047,0.0001543585,0.0002187654,0.0001260317,0.0002018985,0.000338983,0.0001834119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959193,"about_ca_system_score_gemma":0.0001213523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006033608,"about_ca_topic_score_gemma":0.0005909075,"domain_scores_codex":[0.9998179,0.00006094866,0.000008845362,0.00004210046,0.00003761687,0.00003255276],"domain_scores_gemma":[0.9998991,0.00002084888,0.00003444628,0.00002203755,0.00001403158,0.000009445106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005760429,0.00002263917,0.0001630907,0.00001882775,0.000004580841,0.00004705957,0.00001959644,0.0001621312,0.9973217,0.0002328255,0.00002919204,0.001920671],"study_design_scores_gemma":[0.000004484549,0.0001254623,0.0003663642,8.86835e-7,0.00000586766,0.00006383724,0.000003875284,0.0004777592,0.9981728,0.00001636714,0.0007603429,0.000001986696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992415,0.0004170469,0.005535512,0.00009730676,0.00001768168,0.00002387007,0.00003911383,0.00005563376,0.001398847],"genre_scores_gemma":[0.9959756,0.0002431238,0.002418303,0.000032343,0.000004418322,0.00001318247,0.00004620465,0.00001076304,0.001256189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006033608,"threshold_uncertainty_score":0.002147079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09445168265934384,"score_gpt":0.411613211441319,"score_spread":0.3171615287819751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}