{"id":"W2602090891","doi":"10.1200/jco.2009.27.15_suppl.4016","title":"High epiregulin (<i>EREG</i>) gene expression plus <i>K-ras</i> wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): Results from NCIC CTG CO.17—A phase III trial of cetuximab versus best supportive care (BSC)","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Queen's University","funders":"","keywords":"Epiregulin; Cetuximab; Medicine; Internal medicine; Oncology; Colorectal cancer; Hazard ratio; Epidermal growth factor receptor; Cancer; Amphiregulin; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002074431,0.0003217585,0.0005118421,0.0002470875,0.0001707021,0.0003218428,0.0002365872,0.0002815762,0.001154158],"category_scores_gemma":[0.001397704,0.0001668496,0.00044554,0.0002456302,0.0003775294,0.0002001069,0.0001680306,0.0007619737,0.0001420312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205121,"about_ca_system_score_gemma":0.0004292279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005614862,"about_ca_topic_score_gemma":0.001805349,"domain_scores_codex":[0.9995157,0.0002593443,0.00002880455,0.00007848145,0.00007280255,0.00004488123],"domain_scores_gemma":[0.9985984,0.0006221589,0.0003311585,0.0001079925,0.00005545768,0.0002848004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2492321,0.003475646,0.6775938,0.0002072887,0.00203165,0.0002867515,0.0001261817,0.00116402,0.02755727,0.00006940819,0.001264077,0.03699184],"study_design_scores_gemma":[0.009949912,0.04080613,0.9279577,0.00002373233,0.003253944,0.0009863188,0.00005678228,0.003090056,0.01213402,0.000138986,0.001572314,0.00003000336],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992073,0.0002797755,0.0001065424,0.00004097149,0.000004461481,0.00002704723,0.0001410294,0.000003576575,0.0001893408],"genre_scores_gemma":[0.9989064,0.00011754,0.0002781323,0.00005689408,0.00002178131,0.00002468357,0.0004085411,0.000002458313,0.0001834907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002074431,"threshold_uncertainty_score":0.01097077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06714499457657482,"score_gpt":0.4433322052200702,"score_spread":0.3761872106434954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}