{"id":"W2602156859","doi":"10.1038/s41531-017-0010-8","title":"LRRK2 levels in immune cells are increased in Parkinson’s disease","year":2017,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; School of Medicine, Emory University; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Parkinson's Foundation; Emory University","keywords":"Immunophenotyping; Immune system; LRRK2; Immunology; Cytokine; Leucine-rich repeat; Cytotoxic T cell; Biology; Immunosenescence; T cell; Medicine; Kinase; Parkinson's disease; Flow cytometry; Cancer research; Disease; Internal medicine; Cell biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004960719,0.0008051584,0.001111852,0.0006036406,0.0004333619,0.0002553267,0.0007097692,0.0002161578,0.0007223114],"category_scores_gemma":[0.0006303419,0.0007780201,0.0005224559,0.0003224901,0.000238912,0.0005587489,0.0003137203,0.0004859448,0.0004868786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006099747,"about_ca_system_score_gemma":0.0008054866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136945,"about_ca_topic_score_gemma":0.0003648725,"domain_scores_codex":[0.9952194,0.0002599853,0.0008881346,0.001471386,0.0009483369,0.00121276],"domain_scores_gemma":[0.9940111,0.00009568515,0.0005808083,0.002611772,0.0001254762,0.002575135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004047918,0.003722144,0.9713144,0.0003400065,0.0001187208,0.01347461,0.0000894473,0.00002644393,0.001078214,0.0001436355,0.0005081223,0.005136296],"study_design_scores_gemma":[0.01080757,0.00009290111,0.9142373,0.0009467775,0.0003848253,0.000005683815,0.00007889036,0.0009622889,0.001103047,0.0008519129,0.06984593,0.0006828794],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893944,0.004361856,0.0000239381,0.001305766,0.0005037272,0.0016917,0.0009887563,0.0001560855,0.001573717],"genre_scores_gemma":[0.9963684,0.0005350176,0.0002531501,0.0008897952,0.0002411698,0.0005876608,0.0001930457,0.0001378964,0.0007938608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06933781,"threshold_uncertainty_score":0.9994671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03101738232479677,"score_gpt":0.2884596899365521,"score_spread":0.2574423076117553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}