{"id":"W2602156859","doi":"10.1038/s41531-017-0010-8","title":"LRRK2 levels in immune cells are increased in Parkinson’s disease","year":2017,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":306,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; School of Medicine, Emory University; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Parkinson's Foundation; Emory University","keywords":"Immunophenotyping; Immune system; LRRK2; Immunology; Cytokine; Leucine-rich repeat; Cytotoxic T cell; Biology; Immunosenescence; T cell; Medicine; Kinase; Parkinson's disease; Flow cytometry; Cancer research; Disease; Internal medicine; Cell biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119035,0.0002494679,0.0003141878,0.0005594603,0.0001817431,0.000295082,0.00008103523,0.0002837051,0.001611321],"category_scores_gemma":[0.0002902447,0.0001365682,0.0001341244,0.0002456387,0.0001620036,0.0001374796,0.0001476809,0.0002457966,0.0002426491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285263,"about_ca_system_score_gemma":0.00003584017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002525233,"about_ca_topic_score_gemma":0.0002768143,"domain_scores_codex":[0.99988,0.00002028634,0.00001684657,0.00003402481,0.00002897543,0.00001996863],"domain_scores_gemma":[0.9998419,0.0000257745,0.00006874289,0.00000710381,0.00002736759,0.00002902416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003901401,0.0001164221,0.3433384,0.0001384156,0.0001359227,0.002700532,0.0003110502,0.0001103108,0.6395916,0.0000542028,0.0004113406,0.009190363],"study_design_scores_gemma":[0.00004361747,0.0004786647,0.9617893,0.0000123535,0.0000609298,0.004346902,0.000194369,0.0003209693,0.03198358,0.00008823147,0.0006746415,0.000006500976],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990134,0.0004890688,0.0001034201,0.00001677305,0.000004337591,0.000003107621,0.0001084917,0.00001038419,0.0002509987],"genre_scores_gemma":[0.9992459,0.0000958164,0.0001334178,0.0000216067,0.000008857262,0.000007965188,0.0001548232,0.000002812759,0.0003288349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611321,"threshold_uncertainty_score":0.005390406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03101738232479677,"score_gpt":0.2884596899365521,"score_spread":0.2574423076117553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}