{"id":"W2602302584","doi":"10.1200/jco.2012.30.15_suppl.4514","title":"A randomized phase II study of OGX-427 plus prednisone (P) versus P alone in patients (pts) with metastatic castration resistant prostate cancer (CRPC).","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Manitoba; Juravinski Cancer Centre; Interior Health; BC Cancer Agency","funders":"","keywords":"Medicine; Prostate cancer; Internal medicine; Chills; Clinical endpoint; Urology; Gastroenterology; Oncology; Cancer; Endocrinology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00170514,0.00212992,0.002801165,0.0005902424,0.0004970358,0.001012679,0.001012138,0.001765455,0.009476157],"category_scores_gemma":[0.001632558,0.001006788,0.001187842,0.0005064988,0.001708353,0.001166878,0.0006474556,0.002807517,0.001440385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008126826,"about_ca_system_score_gemma":0.001775466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008960898,"about_ca_topic_score_gemma":0.001839859,"domain_scores_codex":[0.9993045,0.0004040746,0.00002821908,0.0001078733,0.00004583429,0.0001094111],"domain_scores_gemma":[0.9990177,0.0002221977,0.0001718315,0.00006779342,0.00003982589,0.0004806244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.970524,0.01382726,0.0004488179,0.0002340061,0.0002029042,0.00004161614,0.00004477621,0.0003680405,0.00296225,0.00009009221,0.000511986,0.01074415],"study_design_scores_gemma":[0.8305454,0.1668482,0.001218744,0.00001365177,0.0001074731,0.00003276855,0.00001961354,0.0003123179,0.0002975746,0.0001269538,0.0004673138,0.00001005237],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985173,0.001354608,0.0006869758,0.0006259136,0.0004402981,0.008677834,0.00094236,0.0001344052,0.001964625],"genre_scores_gemma":[0.977515,0.001470682,0.001849041,0.001323566,0.0005487034,0.01120739,0.00111998,0.00003611356,0.004929459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009476157,"threshold_uncertainty_score":0.03170091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1129619265277054,"score_gpt":0.4852489597762404,"score_spread":0.372287033248535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}