{"id":"W2602346878","doi":"10.1080/15265161.2017.1284922","title":"A Rationale for Relaxing the Requirement to Undergo a Noncurative Chemotherapy for Advanced Cancer in a Phase I Immunotherapy Trial","year":2017,"lang":"en","type":"letter","venue":"The American Journal of Bioethics","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; McGill University","keywords":"Immunotherapy; Chemotherapy; Medicine; Cancer; Bioethics; Clinical trial; Phase (matter); Cancer chemotherapy; Oncology; Intensive care medicine; Internal medicine; Political science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03764719,0.0008578786,0.001179345,0.0008078072,0.006511178,0.005575902,0.00366421,0.09945117,0.005033347],"category_scores_gemma":[0.0909707,0.001402913,0.002343178,0.0008841341,0.008644268,0.00474212,0.003324067,0.07799792,0.005452615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006057025,"about_ca_system_score_gemma":0.01974319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003655884,"about_ca_topic_score_gemma":0.008007656,"domain_scores_codex":[0.9698916,0.01612906,0.003562272,0.001906543,0.006463178,0.002047315],"domain_scores_gemma":[0.9341015,0.04586479,0.00397301,0.001907855,0.007840555,0.006312356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002064382,0.00008553448,0.0009062628,0.0001012129,0.00003410093,0.001936543,0.0003746643,0.0002162647,0.0008327168,0.02990212,0.954991,0.01041307],"study_design_scores_gemma":[0.0006337493,0.000369003,0.001521534,0.001024673,0.00009976188,0.003501648,0.0004730744,0.001198791,0.001017158,0.02834347,0.961634,0.0001829523],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006680509,0.0008133712,0.0003845295,0.9868579,0.006587433,0.00004328367,0.00004678068,0.00003041804,0.004568178],"genre_scores_gemma":[0.002513705,0.0002534699,0.0005119672,0.9892819,0.005363731,0.00006886824,0.00002038969,0.000009773566,0.001976159],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09945117,"threshold_uncertainty_score":0.1990997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4711558231973256,"score_gpt":0.6158556958065379,"score_spread":0.1446998726092123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}