{"id":"W2602370702","doi":"10.1016/j.antiviral.2017.03.016","title":"Comparison of three cell-based drug screening platforms for HSV-1 infection","year":2017,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institutes of Health; Pittsburgh Center for Kidney Research, University of Pittsburgh; National Institute of Diabetes and Digestive and Kidney Diseases; Fogarty International Center; Scioto Foundation","keywords":"Vero cell; Herpes simplex virus; Virology; Antiviral drug; Neurotropic virus; Encephalitis; Drug; Neurotoxicity; Lytic cycle; Induced pluripotent stem cell; Progenitor cell; HSL and HSV; Biology; Virus; Neural stem cell; Cell culture; Pharmacology; Immunology; Medicine; Stem cell; Toxicity; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006314074,0.0007622372,0.001042403,0.001149196,0.0004519587,0.00166893,0.0006990963,0.0008904231,0.00271084],"category_scores_gemma":[0.001020913,0.0003603497,0.0008673647,0.0006810462,0.0003284042,0.0006477652,0.0006480279,0.0006859782,0.0009348553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004627418,"about_ca_system_score_gemma":0.0005362299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193595,"about_ca_topic_score_gemma":0.002266341,"domain_scores_codex":[0.999293,0.000146635,0.00005556483,0.00008970426,0.0003014781,0.000113684],"domain_scores_gemma":[0.9994149,0.000270629,0.00005747711,0.00005780557,0.0001320462,0.0000672541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003468521,0.001278136,0.002074156,0.0007118796,0.000238422,0.0001609399,0.0001167187,0.003071988,0.938427,0.0005337032,0.001173055,0.04874558],"study_design_scores_gemma":[0.0001844154,0.006302778,0.004439917,0.00003691509,0.0003941247,0.0002343339,0.0001502974,0.006517359,0.9758351,0.0001539262,0.005685306,0.00006552445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756329,0.007871749,0.007702688,0.0005241479,0.0002472978,0.0004129106,0.002207583,0.0003171395,0.005083517],"genre_scores_gemma":[0.9649909,0.009740207,0.01507498,0.0003493454,0.00005230596,0.0004546327,0.003424057,0.00005249451,0.005861087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00271084,"threshold_uncertainty_score":0.009068668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2812236842830241,"score_gpt":0.5167682611950645,"score_spread":0.2355445769120403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}