{"id":"W2602384610","doi":"10.1016/j.celrep.2017.02.065","title":"Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Princess Margaret Cancer Foundation; Fraternal Order of Eagles; CureSearch for Children's Cancer; Children's Neuroblastoma Cancer Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; V Foundation for Cancer Research","keywords":"Neuroblastoma; PTPN11; Cancer research; Biology; Zebrafish; MAPK/ERK pathway; Penetrance; Neuroblast; Signal transduction; Phenotype; Gene; Cell biology; Genetics; Mutation; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236416,0.0005105459,0.000216287,0.0002986174,0.0002322794,0.0003247419,0.0001837049,0.0002545607,0.0006666429],"category_scores_gemma":[0.000115678,0.0001346119,0.0001879323,0.00009384617,0.0002832389,0.00025248,0.0005427824,0.0003682758,0.0001340513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004201877,"about_ca_system_score_gemma":0.000352486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008174123,"about_ca_topic_score_gemma":0.002236547,"domain_scores_codex":[0.9998968,0.00003101797,0.000007566176,0.00001474016,0.0000255917,0.00002432157],"domain_scores_gemma":[0.9999261,0.00000917053,0.00001805926,0.000007748401,0.000009584711,0.0000293017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003523953,0.00002443299,0.003341161,0.000109554,0.0000200306,0.001118742,0.00005226911,0.0002646086,0.9897392,0.001543345,0.0001211151,0.003313098],"study_design_scores_gemma":[0.0001401265,0.0006250708,0.07708781,0.00007655209,0.0001437005,0.006209931,0.0002895265,0.005201902,0.8927138,0.001519386,0.01596806,0.00002408841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852769,0.008961828,0.002364759,0.000354012,0.00002585692,0.00002479068,0.0001301029,0.00006726363,0.002794584],"genre_scores_gemma":[0.9959502,0.00211376,0.0009497465,0.00002609628,0.000006956622,0.00001360775,0.00006126859,0.000005698426,0.0008726762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008174123,"threshold_uncertainty_score":0.003048658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352441763015717,"score_gpt":0.3373079875933884,"score_spread":0.3037835699632312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}