{"id":"W2602591433","doi":"10.15252/msb.20167430","title":"Systematic protein–protein interaction mapping for clinically relevant human GPCRs","year":2017,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Regina; Princess Margaret Cancer Centre; Public Health Ontario; Institute for Research in Immunology and Cancer; University Health Network; University of Toronto","funders":"H2020 European Research Council; Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Université Paris Descartes; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; American Roentgen Ray Society; Ministerio de Economía y Competitividad; Generalitat de Catalunya; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; International Business Machines Corporation; Institució Catalana de Recerca i Estudis Avançats; Saskatchewan Health Research Foundation; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Canada Foundation for Innovation; Ontario Genomics Institute; Fondation pour la Recherche Médicale; Canadian Cancer Society; University Health Network; Cystic Fibrosis Canada; National Science Foundation; Fundació la Marató de TV3; Association pour la Recherche sur le Cancer","keywords":"Interactome; G protein-coupled receptor; Biology; Druggability; Computational biology; Proteomics; Membrane protein; Integral membrane protein; Protein–protein interaction; Signal transduction; Cell biology; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00122941,0.0002899496,0.0005718521,0.00007492819,0.0005233951,0.0001830391,0.0006086397,0.0004642645,0.000009412232],"category_scores_gemma":[0.0006871144,0.0002525403,0.000307963,0.00002716895,0.00009552085,0.000008985066,0.000190126,0.0001514346,0.00001968398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003400312,"about_ca_system_score_gemma":0.00005057942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009579064,"about_ca_topic_score_gemma":0.000009726826,"domain_scores_codex":[0.9975226,0.0003488784,0.000906317,0.0006793373,0.0001163711,0.0004264962],"domain_scores_gemma":[0.9976283,0.00002013479,0.0009146607,0.00111531,0.0002131095,0.0001085176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005038694,0.00003208004,0.00005416914,0.001977738,0.0001842196,0.000007027229,0.00002115531,0.00001729736,0.9922079,0.005269594,0.00005241299,0.0001259639],"study_design_scores_gemma":[0.001674755,0.00196625,0.00002800998,0.00413663,0.00008519894,0.00006461867,0.0003330877,0.001146237,0.9798572,0.001319417,0.008573543,0.0008150235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7688456,0.0007953558,0.2254937,0.0001318619,0.0009530859,0.003132632,0.00002146946,0.00003787411,0.0005884483],"genre_scores_gemma":[0.995393,0.000009503028,0.001801566,0.00006669162,0.0004128476,0.001140787,0.0001269276,0.00005644234,0.0009922674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2265474,"threshold_uncertainty_score":0.9999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885476301491379,"score_gpt":0.3200606568607255,"score_spread":0.2912058938458117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}