{"id":"W2602591433","doi":"10.15252/msb.20167430","title":"Systematic protein–protein interaction mapping for clinically relevant human GPCRs","year":2017,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Regina; Princess Margaret Cancer Centre; Public Health Ontario; Institute for Research in Immunology and Cancer; University Health Network; University of Toronto","funders":"H2020 European Research Council; Instituto de Salud Carlos III; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Université Paris Descartes; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; American Roentgen Ray Society; Ministerio de Economía y Competitividad; Generalitat de Catalunya; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; International Business Machines Corporation; Institució Catalana de Recerca i Estudis Avançats; Saskatchewan Health Research Foundation; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Canada Foundation for Innovation; Ontario Genomics Institute; Fondation pour la Recherche Médicale; Canadian Cancer Society; University Health Network; Cystic Fibrosis Canada; National Science Foundation; Fundació la Marató de TV3; Association pour la Recherche sur le Cancer","keywords":"Interactome; G protein-coupled receptor; Biology; Druggability; Computational biology; Proteomics; Membrane protein; Integral membrane protein; Protein–protein interaction; Signal transduction; Cell biology; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832734,0.0003672806,0.0005252708,0.0009263037,0.0003408886,0.0003157929,0.0002644402,0.0002727325,0.001068763],"category_scores_gemma":[0.0004638581,0.0001578945,0.00042868,0.0007121232,0.000150918,0.0001893345,0.0005087788,0.0004160459,0.0005147775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548584,"about_ca_system_score_gemma":0.0003395016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006587034,"about_ca_topic_score_gemma":0.00138903,"domain_scores_codex":[0.9997453,0.00005570101,0.00001793508,0.00007422704,0.00007344768,0.00003350282],"domain_scores_gemma":[0.9998361,0.00005725029,0.00003365699,0.00002820522,0.0000255921,0.00001922228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872774,0.00002992868,0.001996047,0.0001143125,0.0000378504,0.0002393091,0.00003707649,0.0004354563,0.986816,0.0002198825,0.0003085622,0.009578303],"study_design_scores_gemma":[0.00004677532,0.0003536446,0.06488288,0.00002995814,0.0001824193,0.003301183,0.0001765893,0.017839,0.890076,0.0009598254,0.02211689,0.00003478862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.906592,0.004885645,0.07907007,0.0003721669,0.00003693727,0.0002348118,0.00609517,0.0007051312,0.002007997],"genre_scores_gemma":[0.8807387,0.002456829,0.1042653,0.0002112508,0.00002003496,0.000221822,0.01045759,0.0001556246,0.001472794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068763,"threshold_uncertainty_score":0.003575385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885476301491379,"score_gpt":0.3200606568607255,"score_spread":0.2912058938458117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}