{"id":"W2602593591","doi":"10.2196/resprot.7198","title":"Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain","year":2017,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Queen's University; Physicians' Services Incorporated Foundation","keywords":"Medicine; Tolerability; Fibromyalgia; Placebo; Randomized controlled trial; Crossover study; Adverse effect; Physical therapy; Mood; Clinical trial; Chronic pain; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02082277,0.0004094433,0.001203861,0.0002025277,0.0005849138,0.0001587299,0.001504288,0.0002114784,0.00001612794],"category_scores_gemma":[0.002016297,0.000198042,0.0006397399,0.0003887338,0.001407892,0.00002382775,0.0003774039,0.0002682428,5.191051e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000726231,"about_ca_system_score_gemma":0.000364147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006873798,"about_ca_topic_score_gemma":0.00006145502,"domain_scores_codex":[0.9934811,0.002439479,0.001332405,0.000692828,0.001250099,0.0008041111],"domain_scores_gemma":[0.9943656,0.001850348,0.0008707196,0.001771913,0.001059787,0.00008168892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9661961,0.008312047,0.00005546301,0.002443796,0.001776161,0.000002437044,0.0003405824,0.000004198092,0.01505593,0.0001641127,0.0009176618,0.004731524],"study_design_scores_gemma":[0.8795252,0.05592806,0.00004325755,0.0004842015,0.00006139906,3.811153e-7,0.0006101311,0.00007644118,0.05769924,0.0001718799,0.005216456,0.0001833819],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.03671715,0.00001762872,0.0008086685,0.0006161232,0.000008914753,0.9616656,0.00006168233,0.000006601204,0.0000975743],"genre_scores_gemma":[0.1172137,0.000005828926,0.0004687274,0.00000478747,0.0001532321,0.8817724,0.00002986739,0.00003780668,0.0003136545],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08667091,"threshold_uncertainty_score":0.8075919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1583711629588183,"score_gpt":0.5255799605916659,"score_spread":0.3672087976328476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}