{"id":"W2602593591","doi":"10.2196/resprot.7198","title":"Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain","year":2017,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Queen's University; Physicians' Services Incorporated Foundation","keywords":"Medicine; Tolerability; Fibromyalgia; Placebo; Randomized controlled trial; Crossover study; Adverse effect; Physical therapy; Mood; Clinical trial; Chronic pain; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01136019,0.004491893,0.006789218,0.001199686,0.001972776,0.001938786,0.003115421,0.005229945,0.04098836],"category_scores_gemma":[0.008150429,0.002071352,0.002706226,0.001447194,0.002642431,0.002086948,0.001343856,0.005531798,0.008895617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001821221,"about_ca_system_score_gemma":0.007333788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118338,"about_ca_topic_score_gemma":0.002741871,"domain_scores_codex":[0.9933974,0.003839842,0.0005017988,0.0008103075,0.0005890875,0.0008616758],"domain_scores_gemma":[0.9967722,0.0005525747,0.000717042,0.0003989747,0.0004596162,0.00109958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9697888,0.01093864,0.000377179,0.002459665,0.0004501617,0.00007830388,0.00009690749,0.0003494883,0.001773571,0.0007017633,0.004551027,0.008434522],"study_design_scores_gemma":[0.9771594,0.01696969,0.0005829931,0.0001512758,0.0001444378,0.00001529893,0.00001395499,0.000199706,0.0001431673,0.0002520652,0.004349445,0.00001855024],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02199725,0.001347529,0.001923268,0.000619225,0.0006368067,0.9677045,0.003085848,0.0002300502,0.002455601],"genre_scores_gemma":[0.01702699,0.0006332576,0.003404943,0.000635777,0.0002340314,0.9754981,0.0008226323,0.00001661748,0.001727625],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04098836,"threshold_uncertainty_score":0.1371197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1583711629588183,"score_gpt":0.5255799605916659,"score_spread":0.3672087976328476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}